Approaches to methylcyclopropanes and a new route to methylenecyclopropanes
Electronic versions
Documents
35.4 MB, PDF document
Abstract
Mycolic acids show an unusual variety of structural features including the a-methyl-trans-cyclopropane (61), which is thought to be a key factor in stopping drugs getting into the cells of Mycobacterium tuberculosis.
The synthesis of an optically pure cyclopropane as an intermediate for the synthesis of the trans-a-methyl mycolic acid was achieved as part of this work by preparation of (88).
The synthesis of an optically pure cyclopropane as an intermediate for the synthesis of the trans-a-methyl mycolic acid was achieved as part of this work by preparation of (88).
Details
| Original language | English |
|---|---|
| Awarding Institution |
|
| Supervisors/Advisors |
|
| Award date | Jul 2004 |