Guanidine glycomimetics
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Abstract
This thesis describes the investigation of methodologies towards the synthesis and
purification of 5-, 6- and 7- membered guanidine heterocycles. Methods include
intermolecul ar epoxide ring opening reactions using guanidine and the intramolecular cyclization reactions of N-Boc-allylguanidines and N-Boc-homoallylguanidines in both epoxide ring opening reactions and palladium mediated cyclisations. The possible utility of these heterocycles as glycosidase inhibitors was investigated using enzymatic assays.
purification of 5-, 6- and 7- membered guanidine heterocycles. Methods include
intermolecul ar epoxide ring opening reactions using guanidine and the intramolecular cyclization reactions of N-Boc-allylguanidines and N-Boc-homoallylguanidines in both epoxide ring opening reactions and palladium mediated cyclisations. The possible utility of these heterocycles as glycosidase inhibitors was investigated using enzymatic assays.
Details
| Original language | English |
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| Award date | 2012 |