The effect of exercise and fish oil capsules on serum blood lipid and lipoprotein levels in 60 pre and post menopausal women was studied for 13 weeks. Subjects were sedentary but healthy women, free from coronary heart disease and not taking any hormone replacements or oral contraceptives or any medication that might affect serum blood lipids or lipoproteins. Women were randomized according to menopausal status into one of three groups, resulting in final group sizes of 20 women in the exercise group, 20 in the exercise + MaxEPA group and 20 in the MaxEPA group. In each group there were 10 premenopausal and 10 postmenopausal women. The exercise programme for both exercise groups consisted of a 45 minute session which included three sections, warm up, aerobic and cool down all performed to music. Sessions were held twice a week _where subjects worked at intensities of between 75 % to 85 % of age related maximum heart rate. Fish oil capsules in the form of MaxEPA, were taken once each day ( 1 g ) by the MaxEPA and the exercise + MaxEPA groups. Fasting triglyceride ( Tg ), total cholesterol ( T-C) and high density lipoproteins ( HDL) were measured at the baseline, 4 weeks, 8 weeks and at 13 weeks. The low density lipoproteins ( .LDL ) and the ratios of T-C / HDL and LDL /HDL were calculated indirectly. Other measurements taken included body weight, percent body fat and blood pressure. A follow up case study in 12 women was conducted for an additional 13 weeks. The results of the main study indicated that total cholesterol and low density lipoprotein levels were significantly higher in postmenopausal than in the premenopausal , women prior to the programme. Total cholesterol decreased significantly at the end of the programme, where all groups demonstrated a decrease except the premenopausal exercise group. Th1 postmenopausal exercise group had the most pronounced decrease ( 0. 88 mmol.r ) in total cholesterol. Low density lipoprotein levels .decreased across all groups at the end of the programme, ,ain this was most noticeable in the postmenopausal exercise group ( 0.71 rnmol T ). The results of high density lipoprotein and triglyceride levels recorded no significant change among all the three experimental groups at the end of the study. T-C / HDL ratio showed a slight decrease at the encl of the programme for the exercise + MaxEPA group and MaxEPA group but not for the exercise group. The results of the follow up study supported the results of the main study and showed a subsequent decrease in T-C, LDL-C and T-C / HDL and LDL / HDL ratios with no change in either HDL or Tg levels. Moderate aerobic exercise performed twice a week over 13 weeks significantly reduced total cholesterol and low density lipoprotein and also increased high density lipoprotein levels when the baseline level was low.