Porth Ymchwil

Dr Andrew Pierce

Darlithydd (Addysgu ac Ymchwil)

Aelodaeth

ORCID: 0000-0001-5995-2469

Contact info

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

1 - 50 o blith 63Maint y tudalen: 50
Trefnu yn ôl: Blwyddyn gyhoeddi
  1. 2024
  2. Cyhoeddwyd

    Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover

    Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Ebr 2024, Yn: eBioMedicine. 102, t. 105064

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  3. 2023

  4. Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

    Pearson, S., Blance, R., Yan, F., Hsieh, Y-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 Mai 2023, Yn: PLoS ONE. 18, 5, 16 t., 0286412.

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  5. Cyhoeddwyd

    Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women

    Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 Mai 2023, Yn: British Journal of Cancer. 128, 9, t. 1723-1732 10 t.

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  6. THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

    Polenkowski, M., Allister, A. B., Burbano de Lara, S., Pierce, A., Geary, B., El Bounkari, O., Wiehlmann, L., Hoffmann, A., Whetton, A. D., Tamura, T. & Tran, D. D. H., 20 Ion 2023, Yn: iScience. 26, 1, 105784.

    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  7. 2022
  8. Cyhoeddwyd

    HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

    Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Hyd 2022, Yn: Oncogene. 41, 44, t. 4841-4854 14 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  9. Cyhoeddwyd

    Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells

    Pearson, S., D. Whitton, A. & Pierce, A., 31 Maw 2022, Yn: PLoS ONE. 17, 3, 11 t., e0266298.

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  10. 2021

  11. Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Gorff 2021, Yn: Cancers.

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  12. Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer

    Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Chwef 2021, Yn: Cancers. 13, 4, t. 718 1 t.

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  13. 2020

  14. EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

    Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Hyd 2020, Yn: Cell Death and Disease. 11

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  15. EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

    Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, Yn: Molecular Biology Reports. 47, 10, t. 8293-8300 8 t.

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  16. Cyhoeddwyd

    Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

    Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, Yn: Leukemia. 34, 2, t. 427-440 14 t.

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  17. 2019

  18. Oncogenic MYC amplifies mitotic perturbations

    Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Awst 2019, Yn: Open Biology.

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  19. AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Ebr 2019, Yn: HemaSphere.

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  20. Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

    Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, Yn: Journal of Proteome Research.

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  21. 2018

  22. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

    Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Meh 2018, Yn: Nucleic Acids Research. 46, 15, t. 7662-7674 13 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  23. 2017

  24. Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

    S, P., AJK, W., R, B., TCP, S., S, T., N, A., AD, W. & A, P., 1 Rhag 2017, Yn: Leukemia. 31

    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  25. Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, Yn: Cell Death and Disease. 8, 6, t. e2875-e2875

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  26. 2016

  27. Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, Yn: Oncotarget.

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  28. Cyhoeddwyd

    Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

    SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, Yn: Nature. 534, t. 341-346

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  29. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

    PA, C., EJ, C., M, A-OD., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, Yn: BMJ Open Respiratory Research.

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  30. MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

    AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, Yn: Oncotarget.

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  31. 2015

  32. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

    M, A-OD., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, Yn: Natur Protocols.

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  33. 2014

  34. A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Rhag 2014, Yn: Bioinformatics. t. 549-558

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  35. The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

    F, P., MT, S., GV, H., LE, H., EK, A., M, A-OD., M, C., A, P., BJ, H., AD, W. & TL, H., 18 Awst 2014, Yn: Stem Cells. 32, 9, t. 2324-2337

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  36. THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

    DD, T., S, S., AJ, W., Pierce, A., O, D-B., L, W., A, K., AD, W. & T, T., 2014, Yn: Nucleic Acids Research. 42, 19

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  37. 2013
  38. Cyhoeddwyd

    A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    AJ, W., A, P., E, J., C, Z., M, A-OD., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Tach 2013, Yn: Molecular and Cellular Proteomics. 3319 t.

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  39. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Hyd 2013, Yn: Leukemia. 27, t. 932-940

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  40. Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

    DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Meh 2013, Yn: PLoS ONE.

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  41. Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility.

    Pierce, A., AD, W., S, M., F, R-K., G, B., KR, C., N, Z. & S, K., 11 Ebr 2013, Yn: Proteomics. 13, 14, t. 2216-2224

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  42. 2012

  43. BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Meh 2012, Yn: Journal of Proteomics. 77, t. 14-26

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  44. Correction: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)

    Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, Yn: PLoS ONE. 8, 6

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  45. 2010

  46. Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFR activation of the interferon response pathways.

    E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Tach 2010, Yn: Stem Cell Research. 5, 3, t. 226-243

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  47. Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

    CF, L., S, G., E, R-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Medi 2010, Yn: Proteomics. 10, 18, t. 3321-3342

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  48. 2009

  49. THOC5 couples M-CSF receptor signaling to transcription factor expression.

    L, C., A, P., M, R., MB, G. S., HG, H., L, Z., T, T. & AD, W., Chwef 2009, Yn: Cellular Signalling. 21, 2, t. 309-316

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  50. 2008

  51. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

    Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 Mai 2008, Yn: Molecular and Cellular Proteomics. 7, 5, t. 853-863

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  52. THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.

    Pierce, A., L, C., HG, H., JR, G., L, Z., BA, W., MB, G. S., T, T., D, S. & AD, W., 15 Ebr 2008, Yn: British Journal of Haematology. 141, 5, t. 641-650

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  53. 2006

  54. Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

    RD, U., DL, S., D, B., CL, W., CJ, M., CA, E., E, J., SA, B., K, B., A, P., E, S. & AD, W., 15 Meh 2006, Yn: Blood. 107, 12, t. 4687-4694

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  55. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

    Pierce, A., Y, L., HG, H., S, T., PJ, O-L., AD, W. & E, S., 31 Maw 2006, Yn: British Journal of Haematology. 133, 3, t. 345-352

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  56. Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance.

    N, U-D., Pierce, A., SE, T., D, X., AD, W. & PJ, O-L., 13 Chwef 2006, Yn: British Journal of Haematology. 132, 6, t. 774-783

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  57. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, Yn: Blood. t. 1716-1723

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  58. 2005

  59. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Awst 2005, Yn: Leukemia. t. 1851-1853

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  60. Cyhoeddwyd

    Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

    Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Gorff 2005, Yn: Molecular and Cellular Proteomics. 4, 7

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  61. Cyhoeddwyd

    Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

    RD, U., DW, S., Y, L., A, P., DG, G. & AD, W., Chwef 2005, Yn: Journal of Biological Chemistry. 280, 8, t. 6316-6326

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  62. 2004

  63. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 Mai 2004, Yn: Blood. t. 3751-3759

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  64. Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

    D, X., Pierce, A., N, U-D., AD, W. & PJ, O-L., Chwef 2004, Yn: Cellular Signalling. 16, 2, t. 145-156

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  65. 2003

  66. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

    AD, W., Y, L., A, P., L, C. & E, S., 15 Hyd 2003, Yn: Blood. 102, 8, t. 2798-2802

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  67. Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Medi 2003, Yn: British Journal of Haematology. 122, 6, t. 985-995

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  68. 2002

  69. Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Tach 2002, Yn: Molecular and Cellular Proteomics. 1, 11, t. 876-884

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  70. Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.

    CA, E., S, A., A, P. & AD, W., 1 Tach 2002, Yn: Blood. 100, 9, t. 3164-3174

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  71. BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

    Pierce, A., E, S., S, A. & AD, W., 2002, Yn: Oncogene. 21, t. 3068-3075

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