Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Jane Noyes
  • David Gough
    University of London
  • Simon Lewin
    Knowledge Centre for the Health Services at the Norwegian Institute of Public Health, Oslo
  • Alain Mayhew
    Ottawa Hospital Research Institute
  • Susan Michie
    University College London
  • Tomas Pantoja
    Pontificia Universidad Católica de Chile, Santiago
  • Mark Petticrew
    London School of Hygiene & Tropical Medicine
  • Kevin Pottie
    University of Ottawa
  • Eva Rehfuess
    University of Munich
  • Ian Shemilt
    University of Cambridge
  • Sasha Shepperd
    University of Oxford
  • Amanda Sowden
    University of York
  • Peter Tugwell
    University of Ottawa
  • Vivian Welch
    University of Ottawa

OBJECTIVES: This article outlines a research and development agenda for systematic reviews that ask complex questions about interventions varying in degree and type of complexity.

STUDY DESIGN AND SETTING: Consensus development by key authors of articles on methodological challenges in systematic reviews of complex interventions, based on a 2-day workshop in Montebello, Canada, January 2012.

RESULTS: There is an urgent need for a more precise and consistently applied lexicon and language to disaggregate several conceptually distinct dimensions of "complexity." Selected current evidence synthesis methods have potential application in reviews where complexity is important. There is a lack of evaluation of methods to better understand the nature of complex interventions and the optimal processes of synthesizing and interpreting evidence from these systematic reviews. Gaps in methods, knowledge, and know-how exist, and there is a need for additional guidance.

CONCLUSION: Understanding how complexity can impact on findings of systematic reviews is critical. Experience in applying methods that have been developed to facilitate this understanding is limited, and the degree to which these approaches improve the systematic review process or transparency is only partially understood. Future research should concentrate on the impact of complexity on the systematic review process and findings and on further methodological development.

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