A unifying motor control framework for task-specific dystonia

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A unifying motor control framework for task-specific dystonia. / Sadnicka, Anna; Kornysheva, Katja; Rothwell, John C. et al.
Yn: Nature Reviews Neurology, Cyfrol 14, 2018, t. 116-124.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl adolyguadolygiad gan gymheiriaid

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Sadnicka, A, Kornysheva, K, Rothwell, JC & Edwards, MJ 2018, 'A unifying motor control framework for task-specific dystonia', Nature Reviews Neurology, cyfrol. 14, tt. 116-124. https://doi.org/10.1038/nrneurol.2017.146

APA

Sadnicka, A., Kornysheva, K., Rothwell, J. C., & Edwards, M. J. (2018). A unifying motor control framework for task-specific dystonia. Nature Reviews Neurology, 14, 116-124. https://doi.org/10.1038/nrneurol.2017.146

CBE

Sadnicka A, Kornysheva K, Rothwell JC, Edwards MJ. 2018. A unifying motor control framework for task-specific dystonia. Nature Reviews Neurology. 14:116-124. https://doi.org/10.1038/nrneurol.2017.146

MLA

VancouverVancouver

Sadnicka A, Kornysheva K, Rothwell JC, Edwards MJ. A unifying motor control framework for task-specific dystonia. Nature Reviews Neurology. 2018;14:116-124. Epub 2017 Tach 6. doi: 10.1038/nrneurol.2017.146

Author

Sadnicka, Anna ; Kornysheva, Katja ; Rothwell, John C. et al. / A unifying motor control framework for task-specific dystonia. Yn: Nature Reviews Neurology. 2018 ; Cyfrol 14. tt. 116-124.

RIS

TY - JOUR

T1 - A unifying motor control framework for task-specific dystonia

AU - Sadnicka, Anna

AU - Kornysheva, Katja

AU - Rothwell, John C.

AU - Edwards, Mark J.

N1 - K.K. is funded by Sir Henry Wellcome Fellowship no. 098881/Z/12/Z

PY - 2018

Y1 - 2018

N2 - Task-specific dystonia is a movement disorder characterized by a painless loss of dexterity specific to a particular motor skill. This disorder is prevalent among writers, musicians, dancers and athletes. No current treatment is predictably effective, and the disorder generally ends the careers of affected individuals. Traditional disease models of dystonia have a number of limitations with regard to task-specific dystonia. We therefore discuss emerging evidence that the disorder has its origins within normal compensatory mechanisms of a healthy motor system in which the representation and reproduction of motor skill are disrupted. We describe how risk factors for task-specific dystonia can be stratified and translated into mechanisms of dysfunctional motor control. The proposed model aims to define new directions for experimental research and stimulate therapeutic advances for this highly disabling disorder.

AB - Task-specific dystonia is a movement disorder characterized by a painless loss of dexterity specific to a particular motor skill. This disorder is prevalent among writers, musicians, dancers and athletes. No current treatment is predictably effective, and the disorder generally ends the careers of affected individuals. Traditional disease models of dystonia have a number of limitations with regard to task-specific dystonia. We therefore discuss emerging evidence that the disorder has its origins within normal compensatory mechanisms of a healthy motor system in which the representation and reproduction of motor skill are disrupted. We describe how risk factors for task-specific dystonia can be stratified and translated into mechanisms of dysfunctional motor control. The proposed model aims to define new directions for experimental research and stimulate therapeutic advances for this highly disabling disorder.

KW - Journal Article

KW - Review

U2 - 10.1038/nrneurol.2017.146

DO - 10.1038/nrneurol.2017.146

M3 - Review article

C2 - 29104291

VL - 14

SP - 116

EP - 124

JO - Nature Reviews Neurology

JF - Nature Reviews Neurology

SN - 1759-4758

ER -