Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Copenhagen
  • Tobias Stoeger
    Helmholtz Zentrum München
  • Sybille van den Brule
    Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain, Avenue E. Mounier 52 - bte B1.52.12, 1200 Brussels, Belgium.
  • Anne Thoustrup Saber
    National Research Centre for the Working Environment, Copenhagen
  • Andrea Beyerle
    Helmholtz Zentrum München
  • Giulia Vietti
    Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain, Avenue E. Mounier 52 - bte B1.52.12, 1200 Brussels, Belgium.
  • Alicja Mortensen
    Technical University of Denmark, Lyngby
  • Józef Szarek
    University of Warmia and Mazury in Olsztyn
  • Hans Christian Budtz
    National Research Centre for the Working Environment, Copenhagen
  • Ali Kermanizadeh
    University of Copenhagen
  • Atrayee Banerjee
    Missouri University of Science and Technology
  • Nuran Ercal
    Missouri University of Science and Technology
  • Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen
  • Håkan Wallin
    National Research Centre for the Working Environment, Copenhagen
  • Peter Møller
    University of Copenhagen

Inhalation is the main pathway of ZnO exposure in the occupational environment but only few studies have addressed toxic effects after pulmonary exposure to ZnO nanoparticles (NP). Here we present results from three studies of pulmonary exposure and toxicity of ZnO NP in mice. The studies were prematurely terminated because interim results unexpectedly showed severe pulmonary toxicity. High bolus doses of ZnO NP (25 up to 100 μg; ≥1.4 mg/kg) were clearly associated with a dose dependent mortality in the mice. Lower doses (≥6 μg; ≥0.3 mg/kg) elicited acute toxicity in terms of reduced weight gain, desquamation of epithelial cells with concomitantly increased barrier permeability of the alveolar/blood as well as DNA damage. Oxidative stress was shown via a strong increase in lipid peroxidation and reduced glutathione in the pulmonary tissue. Two months post-exposure revealed no obvious toxicity for 12.5 and 25 μg on a range of parameters. However, mice that survived a high dose (50 μg; 2.7 mg/kg) had an increased pulmonary collagen accumulation (fibrosis) at a similar level as a high bolus dose of crystalline silica. The recovery from these toxicological effects appeared dose-dependent. The results indicate that alveolar deposition of ZnO NP may cause significant adverse health effects.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)84-95
Nifer y tudalennau12
CyfnodolynFood and chemical toxicology
Cyfrol85
Dyddiad ar-lein cynnar7 Awst 2015
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Tach 2015
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau