Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Geoff B Coombs
    University of British Columbia, Okanagan
  • Otto F Barak
    University of Novi Sad
  • Aaron A Phillips
    University of Calgary
  • Tanja Mijacika
    University of Split
  • Zoe K Sarafis
    University of British Columbia
  • Amanda H X Lee
    University of British Columbia
  • Jordan W Squair
    University of British Columbia
  • Tyler D Bammert
    University of Colorado
  • Noah M DeSouza
    University of Colorado
  • Daniel Gagnon
    Montreal Heart Institute Research Centre
  • Andrei V Krassioukov
    University of British Columbia
  • Zeljko Dujic
    University of Split
  • Christopher A DeSouza
    University of Colorado
  • Philip N Ainslie
    University of British Columbia, Okanagan

Cardiovascular diseases (CVD) are highly prevalent in spinal cord injury (SCI), and peripheral vascular dysfunction might be a contributing factor. Recent evidence demonstrates that exposure to heat stress can improve vascular function and reduce the risk of CVD in uninjured populations. We therefore aimed to examine the extent of vascular dysfunction in SCI and the acute effects of passive heating. Fifteen participants with cervical SCI and 15 uninjured control (CON) participants underwent ultrasound assessments of vascular function and venous blood sampling for biomarkers of endothelial activation (i.e., CD62e+) and apoptosis (i.e., CD31+/42b-) before and after a 60-min exposure to lower limb hot water immersion (40°C). In SCI, macrovascular endothelial function was reduced in the brachial artery [SCI: 4.8 (3.2)% vs. CON: 7.6 (3.4)%, P = 0.04] but not the femoral artery [SCI: 3.7 (2.6)% vs. CON: 4.0 (2.1)%, P = 0.70]. Microvascular function, via reactive hyperemia, was ~40% lower in SCI versus CON in both the femoral and brachial arteries ( P < 0.01). Circulating concentrations of CD62e+ were elevated in SCI versus CON [SCI: 152 (106) microparticles/µl vs. CON: 58 (24) microparticles/µl, P < 0.05]. In response to heating, macrovascular and microvascular function remained unchanged, whereas increases (+83%) and decreases (-93%) in antegrade and retrograde shear rates, respectively, were associated with heat-induced reductions of CD62e+ concentrations in SCI to levels similar to CON ( P = 0.05). These data highlight the potential of acute heating to provide a safe and practical strategy to improve vascular function in SCI. The chronic effects of controlled heating warrant long-term testing. NEW & NOTEWORTHY Individuals with cervical level spinal cord injury exhibit selectively lower flow-mediated dilation in the brachial but not femoral artery, whereas peak reactive hyperemia was lower in both arteries compared with uninjured controls. After 60 min of lower limb hot water immersion, femoral artery blood flow and shear patterns were acutely improved in both groups. Elevated biomarkers of endothelial activation in the spinal cord injury group decreased with heating, but these biomarkers remained unchanged in controls.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)H722-H733
CyfnodolynAmerican Journal of Physiology - Heart and Circulatory Physiology
Cyfrol316
Rhif y cyfnodolyn3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Maw 2019
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau