An exploratory study to investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in adult males
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Purpose To investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers
of tissue metabolism in a cross-sectional sample of adult males. This study utilizes several emerging biomarkers that have
been associated with early joint degenerative changes; serum COMP (cartilage oligomeric matrix protein), HA (hyaluronan)
and lubricin.
Methods Eighty-one males (age: mean (range): 43(18–70) years; body mass index: 25.2 (21.0–30.6) kg/m2) volunteered.
Resting serum COMP, HA and lubricin concentrations were determined via commercially available enzyme-linked immunosorbent
assay (ELISA) and femoral trochlear cartilage thickness via supra-patellar ultrasound imaging. Physical activity
levels were assessed using questionnaires. Statistical analyses were performed using correlation and regression analyses.
Results Age was correlated with lateral trochlear cartilage thickness (r = − 0.372; p < 0.01) and serum COMP (r = 0.342;
p < 0.01). 7-day physical activity was correlated with serum COMP (r = 0.357, p < 0.01), and 12-month physical activity
with both lateral trochlear cartilage thickness (r = 0.340, p = 0.01) and serum HA (r = 0.296, p < 0.05). Regression analyses
revealed that age significantly accounted for the variability in lateral cartilage thickness and serum COMP, following the
adjustment for potential cofounders. However, the association between age and lateral trochlear cartilage thickness was not
moderated by physical activity levels (all p > 0.05).
Conclusion This study indicates that older age may be associated with thinner lateral trochlear cartilage and higher cartilage
turnover. Being physically active may also be positive for lateral trochlear cartilage thickness. However, overall, both age
and physical activity level only account for a small amount of the variability in cartilage thickness and serum biomarkers.
Allweddeiriau
Iaith wreiddiol | Saesneg |
---|---|
Tudalennau (o-i) | 1871-1880 |
Nifer y tudalennau | 10 |
Cyfnodolyn | European Journal of Applied Physiology |
Cyfrol | 121 |
Rhif y cyfnodolyn | 7 |
Dyddiad ar-lein cynnar | 13 Maw 2021 |
Dynodwyr Gwrthrych Digidol (DOIs) | |
Statws | Cyhoeddwyd - Gorff 2021 |
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