Fersiynau electronig

Dogfennau

Dangosydd eitem ddigidol (DOI)

  • Harry Roberts
  • Claire Griffith-Mcgeever
  • Julian Owen
  • Lewis Angell
    School of Sport, Health and Exercise Sciences, Bangor University, Bangor, United Kingdom
  • Jonathan Moore
  • Jeanette Thom
Purpose To investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in a cross-sectional sample of adult males. This study utilizes several emerging biomarkers that have been associated with early joint degenerative changes; serum COMP (cartilage oligomeric matrix protein), HA (hyaluronan) and lubricin. Methods Eighty-one males (age: mean (range): 43(18–70) years; body mass index: 25.2 (21.0–30.6) kg/m2) volunteered. Resting serum COMP, HA and lubricin concentrations were determined via commercially available enzyme-linked immunosorbent assay (ELISA) and femoral trochlear cartilage thickness via supra-patellar ultrasound imaging. Physical activity levels were assessed using questionnaires. Statistical analyses were performed using correlation and regression analyses. Results Age was correlated with lateral trochlear cartilage thickness (r = − 0.372; p < 0.01) and serum COMP (r = 0.342; p < 0.01). 7-day physical activity was correlated with serum COMP (r = 0.357, p < 0.01), and 12-month physical activity with both lateral trochlear cartilage thickness (r = 0.340, p = 0.01) and serum HA (r = 0.296, p < 0.05). Regression analyses revealed that age significantly accounted for the variability in lateral cartilage thickness and serum COMP, following the adjustment for potential cofounders. However, the association between age and lateral trochlear cartilage thickness was not moderated by physical activity levels (all p > 0.05). Conclusion This study indicates that older age may be associated with thinner lateral trochlear cartilage and higher cartilage turnover. Being physically active may also be positive for lateral trochlear cartilage thickness. However, overall, both age and physical activity level only account for a small amount of the variability in cartilage thickness and serum biomarkers.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)1871-1880
Nifer y tudalennau10
CyfnodolynEuropean Journal of Applied Physiology
Cyfrol121
Rhif y cyfnodolyn7
Dyddiad ar-lein cynnar13 Maw 2021
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Gorff 2021

Cyfanswm lawlrlwytho

Nid oes data ar gael
Gweld graff cysylltiadau