Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. / Heffernan, Shane M.; Kilduff, Liam P.; Erskine, Robert M. et al.
Yn: Physical Genomics, Cyfrol 48, Rhif 3, 01.03.2016, t. 196-201.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Heffernan, SM, Kilduff, LP, Erskine, RM, Day, SH, McPhee, JS, McMahon, GE, Stebbings, GK, Neale, JPH, Lockey, SJ, Ribbans, WJ, Cook, C, Vance, B, Raleigh, SM, Roberts, C, Bennett, MA, Wang, G, Collins, M, Pitsiladis, YP & Williams, AG 2016, 'Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position.', Physical Genomics, cyfrol. 48, rhif 3, tt. 196-201. https://doi.org/10.1152/physiolgenomics.00107.2015

APA

Heffernan, S. M., Kilduff, L. P., Erskine, R. M., Day, S. H., McPhee, J. S., McMahon, G. E., Stebbings, G. K., Neale, J. P. H., Lockey, S. J., Ribbans, W. J., Cook, C., Vance, B., Raleigh, S. M., Roberts, C., Bennett, M. A., Wang, G., Collins, M., Pitsiladis, Y. P., & Williams, A. G. (2016). Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. Physical Genomics, 48(3), 196-201. https://doi.org/10.1152/physiolgenomics.00107.2015

CBE

Heffernan SM, Kilduff LP, Erskine RM, Day SH, McPhee JS, McMahon GE, Stebbings GK, Neale JPH, Lockey SJ, Ribbans WJ, et al. 2016. Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. Physical Genomics. 48(3):196-201. https://doi.org/10.1152/physiolgenomics.00107.2015

MLA

VancouverVancouver

Heffernan SM, Kilduff LP, Erskine RM, Day SH, McPhee JS, McMahon GE et al. Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. Physical Genomics. 2016 Maw 1;48(3):196-201. Epub 2016 Ion 12. doi: 10.1152/physiolgenomics.00107.2015

Author

Heffernan, Shane M. ; Kilduff, Liam P. ; Erskine, Robert M. et al. / Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. Yn: Physical Genomics. 2016 ; Cyfrol 48, Rhif 3. tt. 196-201.

RIS

TY - JOUR

T1 - Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position.

AU - Heffernan, Shane M.

AU - Kilduff, Liam P.

AU - Erskine, Robert M.

AU - Day, Stephen H.

AU - McPhee, Jamie S.

AU - McMahon, Gerald Eugene

AU - Stebbings, Georgina Kate

AU - Neale, Joshua P.H.

AU - Lockey, Sarah J.

AU - Ribbans, William J.

AU - Cook, Christian

AU - Vance, Beth

AU - Raleigh, Stuart M.

AU - Roberts, Craig

AU - Bennett, Mark A.

AU - Wang, Guan

AU - Collins, Mark

AU - Pitsiladis, Yannis P.

AU - Williams, Alun G.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - We aimed to quantify the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league), compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian men, including 431 rugby union athletes that for some analyses were divided into backs and forwards and into specific positional groups: front five, back row, half backs, centers and back three. Controls were 710 Caucasian men and women. Real-time PCR of genomic DNA was used to determine genotypes using TaqMan probes and groups were compared using Chi-square and odds ratio (OR) statistics. Correction of p-values for multiple comparisons was according to Benjamini-Hochberg. There was no difference in ACE I/D genotype between groups. ACTN3 XX genotype tended to be underrepresented in rugby union backs (15.7%) compared to forwards (24.8%; P=0.06). Interestingly, the 69 back three players (wings and full backs) in rugby union included only six XX genotype individuals (8.7%), with the R allele more common in the back three (68.8%) than controls (58.0%; χ2=6.672, P=0.04; OR=1.60) and forwards (47.5%; χ2=11.768, P=0.01; OR=2.00). Association of ACTN3 R577X with playing position in elite rugby union athletes suggests inherited fatigue resistance is more prevalent in forwards while inherited sprint ability is more prevalent in backs, especially wings and full backs. These results also demonstrate the advantage of focusing genetic studies on a large cohort within a single sport, especially when intra-sport positional differences exist, instead of combining several sports with varied demands and athlete characteristics

AB - We aimed to quantify the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league), compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian men, including 431 rugby union athletes that for some analyses were divided into backs and forwards and into specific positional groups: front five, back row, half backs, centers and back three. Controls were 710 Caucasian men and women. Real-time PCR of genomic DNA was used to determine genotypes using TaqMan probes and groups were compared using Chi-square and odds ratio (OR) statistics. Correction of p-values for multiple comparisons was according to Benjamini-Hochberg. There was no difference in ACE I/D genotype between groups. ACTN3 XX genotype tended to be underrepresented in rugby union backs (15.7%) compared to forwards (24.8%; P=0.06). Interestingly, the 69 back three players (wings and full backs) in rugby union included only six XX genotype individuals (8.7%), with the R allele more common in the back three (68.8%) than controls (58.0%; χ2=6.672, P=0.04; OR=1.60) and forwards (47.5%; χ2=11.768, P=0.01; OR=2.00). Association of ACTN3 R577X with playing position in elite rugby union athletes suggests inherited fatigue resistance is more prevalent in forwards while inherited sprint ability is more prevalent in backs, especially wings and full backs. These results also demonstrate the advantage of focusing genetic studies on a large cohort within a single sport, especially when intra-sport positional differences exist, instead of combining several sports with varied demands and athlete characteristics

U2 - 10.1152/physiolgenomics.00107.2015

DO - 10.1152/physiolgenomics.00107.2015

M3 - Article

VL - 48

SP - 196

EP - 201

JO - Physical Genomics

JF - Physical Genomics

SN - 1094-8341

IS - 3

ER -