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Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2. / Carr, Jay Mjr; Ainslie, Philip N; MacLeod, David B et al.
Yn: Journal of Cerebral Blood Flow and Metabolism, Cyfrol 43, Rhif 1, 01.2023, t. 99-114.

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HarvardHarvard

Carr, JM, Ainslie, PN, MacLeod, DB, Tremblay, JC, Nowak-Flück, D, Howe, CA, Stembridge, M, Patrician, A, Coombs, GB, Stacey, BS, Bailey, DM, Green, DJ & Hoiland, RL 2023, 'Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2', Journal of Cerebral Blood Flow and Metabolism, cyfrol. 43, rhif 1, tt. 99-114. https://doi.org/10.1177/0271678X221119442

APA

Carr, J. M., Ainslie, P. N., MacLeod, D. B., Tremblay, J. C., Nowak-Flück, D., Howe, C. A., Stembridge, M., Patrician, A., Coombs, G. B., Stacey, B. S., Bailey, D. M., Green, D. J., & Hoiland, R. L. (2023). Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2. Journal of Cerebral Blood Flow and Metabolism, 43(1), 99-114. https://doi.org/10.1177/0271678X221119442

CBE

Carr JM, Ainslie PN, MacLeod DB, Tremblay JC, Nowak-Flück D, Howe CA, Stembridge M, Patrician A, Coombs GB, Stacey BS, et al. 2023. Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2. Journal of Cerebral Blood Flow and Metabolism. 43(1):99-114. https://doi.org/10.1177/0271678X221119442

MLA

VancouverVancouver

Carr JM, Ainslie PN, MacLeod DB, Tremblay JC, Nowak-Flück D, Howe CA et al. Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2. Journal of Cerebral Blood Flow and Metabolism. 2023 Ion;43(1):99-114. Epub 2022 Medi 21. doi: 10.1177/0271678X221119442

Author

Carr, Jay Mjr ; Ainslie, Philip N ; MacLeod, David B et al. / Cerebral O2 and CO2 transport in isovolumic haemodilution : Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2. Yn: Journal of Cerebral Blood Flow and Metabolism. 2023 ; Cyfrol 43, Rhif 1. tt. 99-114.

RIS

TY - JOUR

T1 - Cerebral O2 and CO2 transport in isovolumic haemodilution

T2 - Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2

AU - Carr, Jay Mjr

AU - Ainslie, Philip N

AU - MacLeod, David B

AU - Tremblay, Joshua C

AU - Nowak-Flück, Daniela

AU - Howe, Connor A

AU - Stembridge, Mike

AU - Patrician, Alexander

AU - Coombs, Geoff B

AU - Stacey, Benjamin S

AU - Bailey, Damian M

AU - Green, Daniel J

AU - Hoiland, Ryan L

PY - 2023/1

Y1 - 2023/1

N2 - This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass index; 23 ± 2 kg/m2). Radial artery and internal jugular vein catheters provided measurement of blood pressure and gases, quantification of cerebral metabolism, cerebral CO2 washout, and trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to and following haemodilution, the partial pressure of arterial CO2 (PaCO2) was elevated with dynamic end-tidal forcing while gCBF was measured with duplex ultrasound. CVR was determined as the slope of the gCBF response and PaCO2. Replacement of ∼20% of blood volume with an equal volume of 5% human serum albumin (Alburex® 5%) reduced haemoglobin (13.8 ± 0.8 vs. 11.3 ± 0.6 g/dL; P < 0.001) and CaO2 (18.9 ± 1.0 vs 15.0 ± 0.8 mL/dL P < 0.001), elevated gCBF (+18 ± 11%; P = 0.002), preserved cerebral oxygen delivery (P = 0.49), and elevated CO2 washout (+11%; P = 0.01). The net cerebral uptake of nitrite (11.6 ± 14.0 nmol/min; P = 0.027) at baseline was abolished following haemodilution (-3.6 ± 17.9 nmol/min; P = 0.54), perhaps underpinning the conservation of CVR (61.7 ± 19.0 vs. 69.0 ± 19.2 mL/min/mmHg; P = 0.23). These findings demonstrate that the cerebrovascular responses to acute anaemia in healthy humans are sufficient to support the maintenance of CVR.

AB - This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass index; 23 ± 2 kg/m2). Radial artery and internal jugular vein catheters provided measurement of blood pressure and gases, quantification of cerebral metabolism, cerebral CO2 washout, and trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to and following haemodilution, the partial pressure of arterial CO2 (PaCO2) was elevated with dynamic end-tidal forcing while gCBF was measured with duplex ultrasound. CVR was determined as the slope of the gCBF response and PaCO2. Replacement of ∼20% of blood volume with an equal volume of 5% human serum albumin (Alburex® 5%) reduced haemoglobin (13.8 ± 0.8 vs. 11.3 ± 0.6 g/dL; P < 0.001) and CaO2 (18.9 ± 1.0 vs 15.0 ± 0.8 mL/dL P < 0.001), elevated gCBF (+18 ± 11%; P = 0.002), preserved cerebral oxygen delivery (P = 0.49), and elevated CO2 washout (+11%; P = 0.01). The net cerebral uptake of nitrite (11.6 ± 14.0 nmol/min; P = 0.027) at baseline was abolished following haemodilution (-3.6 ± 17.9 nmol/min; P = 0.54), perhaps underpinning the conservation of CVR (61.7 ± 19.0 vs. 69.0 ± 19.2 mL/min/mmHg; P = 0.23). These findings demonstrate that the cerebrovascular responses to acute anaemia in healthy humans are sufficient to support the maintenance of CVR.

KW - Humans

KW - Carbon Dioxide

KW - Health Status

U2 - 10.1177/0271678X221119442

DO - 10.1177/0271678X221119442

M3 - Article

C2 - 36131560

VL - 43

SP - 99

EP - 114

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 1

ER -