TY - JOUR

T1 - Chronic alcohol exposure decreases brain intracellular free magnesium concentration in rats

AU - Mullins, P G

AU - Vink, R

PY - 1995/8/21

Y1 - 1995/8/21

N2 - Phosphorus magnetic resonance spectroscopy was used to determine effects of acute and chronic alcohol exposure on brain intracellular free magnesium concentration (Mgf) and bioenergetic state in rats. Acute alcohol (3 mg kg-1, i.p.) resulted in a transient ( < 2h) decline in brain Mgf and cytosolic phosphorylation ratio, and an increase in mitochondrial oxidative capacity. In contrast, chronic exposure to alcohol for 30 days by vapour inhalation resulted in a depletion of brain Mgf with no significant change in bioenergetic parameters. Subsequent exposure of chronically alcoholised rats to an acute dose of alcohol (3 g kg-1) did not result in any further changes. We conclude that chronic exposure to alcohol results in a depletion of brain Mgf and compromised bioenergetic regulation.

AB - Phosphorus magnetic resonance spectroscopy was used to determine effects of acute and chronic alcohol exposure on brain intracellular free magnesium concentration (Mgf) and bioenergetic state in rats. Acute alcohol (3 mg kg-1, i.p.) resulted in a transient ( < 2h) decline in brain Mgf and cytosolic phosphorylation ratio, and an increase in mitochondrial oxidative capacity. In contrast, chronic exposure to alcohol for 30 days by vapour inhalation resulted in a depletion of brain Mgf with no significant change in bioenergetic parameters. Subsequent exposure of chronically alcoholised rats to an acute dose of alcohol (3 g kg-1) did not result in any further changes. We conclude that chronic exposure to alcohol results in a depletion of brain Mgf and compromised bioenergetic regulation.

KW - Administration, Inhalation

KW - Animals

KW - Brain

KW - Energy Metabolism

KW - Ethanol

KW - Hydrogen-Ion Concentration

KW - Magnesium

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Mitochondria

KW - Phosphorylation

KW - Rats

KW - Rats, Sprague-Dawley

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 8527730

VL - 6

SP - 1633

EP - 1636

JO - Neuroreport

JF - Neuroreport

SN - 0959-4965

IS - 12

ER -