TY - JOUR

T1 - Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks

AU - Souter, Nicholas E.

AU - de Freitas, Antonia

AU - Zhang, Meichao

AU - Shao, Ximing

AU - del Jesus Gonzalez Alam, Tirso Rene

AU - Engen, Haakon

AU - Smallwood, Jonathan

AU - Krieger-Redwood, Katya

AU - Jefferies, Elizabeth

N1 - © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

PY - 2024/5/8

Y1 - 2024/5/8

N2 - The default mode network (DMN) lies towards the heteromodal end of the principal gradient of intrinsic connectivity, maximally separated from the sensory-motor cortex. It supports memory-based cognition, including the capacity to retrieve conceptual and evaluative information from sensory inputs, and to generate meaningful states internally; however, the functional organisation of DMN that can support these distinct modes of retrieval remains unclear. We used fMRI to examine whether activation within subsystems of DMN differed as a function of retrieval demands, or the type of association to be retrieved, or both. In a picture association task, participants retrieved semantic associations that were either contextual or emotional in nature. Participants were asked to avoid generating episodic associations. In the generate phase, these associations were retrieved from a novel picture, while in the switch phase, participants retrieved a new association for the same image. Semantic context and emotion trials were associated with dissociable DMN subnetworks, indicating that a key dimension of DMN organisation relates to the type of association being accessed. The frontotemporal and medial temporal DMN showed a preference for emotional and semantic contextual associations, respectively. Relative to the generate phase, the switch phase recruited clusters closer to the heteromodal apex of the principal gradient-a cortical hierarchy separating unimodal and heteromodal regions. There were no differences in this effect between association types. Instead, memory switching was associated with a distinct subnetwork associated with controlled internal cognition. These findings delineate distinct patterns of DMN recruitment for different kinds of associations yet common responses across tasks that reflect retrieval demands. [Abstract copyright: © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.]

AB - The default mode network (DMN) lies towards the heteromodal end of the principal gradient of intrinsic connectivity, maximally separated from the sensory-motor cortex. It supports memory-based cognition, including the capacity to retrieve conceptual and evaluative information from sensory inputs, and to generate meaningful states internally; however, the functional organisation of DMN that can support these distinct modes of retrieval remains unclear. We used fMRI to examine whether activation within subsystems of DMN differed as a function of retrieval demands, or the type of association to be retrieved, or both. In a picture association task, participants retrieved semantic associations that were either contextual or emotional in nature. Participants were asked to avoid generating episodic associations. In the generate phase, these associations were retrieved from a novel picture, while in the switch phase, participants retrieved a new association for the same image. Semantic context and emotion trials were associated with dissociable DMN subnetworks, indicating that a key dimension of DMN organisation relates to the type of association being accessed. The frontotemporal and medial temporal DMN showed a preference for emotional and semantic contextual associations, respectively. Relative to the generate phase, the switch phase recruited clusters closer to the heteromodal apex of the principal gradient-a cortical hierarchy separating unimodal and heteromodal regions. There were no differences in this effect between association types. Instead, memory switching was associated with a distinct subnetwork associated with controlled internal cognition. These findings delineate distinct patterns of DMN recruitment for different kinds of associations yet common responses across tasks that reflect retrieval demands. [Abstract copyright: © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.]

KW - Adult

KW - Brain Mapping

KW - Cerebral Cortex - physiology - diagnostic imaging

KW - Default Mode Network - physiology - diagnostic imaging

KW - Emotions - physiology

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Mental Recall - physiology

KW - Nerve Net - physiology - diagnostic imaging

KW - Pattern Recognition, Visual - physiology

KW - Semantics

KW - Young Adult

KW - association

KW - context

KW - default

KW - emotion

KW - gradient

KW - semantic

KW - switch

U2 - 10.1002/hbm.26703

DO - 10.1002/hbm.26703

M3 - Article

C2 - 38716714

VL - 45

SP - e26703

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 7

M1 - e26703

ER -