TY - JOUR

T1 - Determinants of carbon nanotube toxicity

AU - Lanone, Sophie

AU - Andujar, Pascal

AU - Kermanizadeh, Ali

AU - Boczkowski, Jorge

N1 - © 2013 Elsevier B.V. All rights reserved.

PY - 2013/12

Y1 - 2013/12

N2 - In the last few years questions have been raised regarding the potential toxicity of carbon nanotubes (CNTs) to humans and environment. It is believed that the physico-chemical characteristics of these materials are key determinants of CNT interaction with living organisms, and hence determine their toxicity. As for other nanomaterials, the most important of these characteristics are the length, diameter, surface area, tendency to agglomerate, bio-durability, presence and nature of catalyst residues as well as chemical functionalization of the CNT. This review highlights the recent advancements in the understanding of the CNT properties which are essential in determining CNT toxicity. Hence the focus is on CNT dimensions, surface properties, bio-durability and corona formation as these fields have evolved greatly in recent years. A deeper understanding of these events and their underlying mechanisms could provide a molecular explanation of the biological and physiological responses following CNT administration and therefore help in the development of safe by design materials.

AB - In the last few years questions have been raised regarding the potential toxicity of carbon nanotubes (CNTs) to humans and environment. It is believed that the physico-chemical characteristics of these materials are key determinants of CNT interaction with living organisms, and hence determine their toxicity. As for other nanomaterials, the most important of these characteristics are the length, diameter, surface area, tendency to agglomerate, bio-durability, presence and nature of catalyst residues as well as chemical functionalization of the CNT. This review highlights the recent advancements in the understanding of the CNT properties which are essential in determining CNT toxicity. Hence the focus is on CNT dimensions, surface properties, bio-durability and corona formation as these fields have evolved greatly in recent years. A deeper understanding of these events and their underlying mechanisms could provide a molecular explanation of the biological and physiological responses following CNT administration and therefore help in the development of safe by design materials.

KW - Animals

KW - Environmental Exposure/adverse effects

KW - Humans

KW - Nanotubes, Carbon/adverse effects

KW - Particle Size

KW - Surface Properties

KW - Toxicity Tests/methods

U2 - 10.1016/j.addr.2013.07.019

DO - 10.1016/j.addr.2013.07.019

M3 - Review article

C2 - 23928473

VL - 65

SP - 2063

EP - 2069

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 15

ER -