TY - JOUR

T1 - Development of encapsulated sage extract powder: Inter-comparison with commercially available powder for physical properties and metabolites composition

AU - Naziruddin, M.A.

AU - Kian, L.K.

AU - Jawaid, M.

AU - Aziman, N.

AU - Yusof, N.L.

AU - Abdul-Mutalib, N.A.

AU - Sanny, M.

AU - Fouad, Hassan

AU - Tverezovskaya, O.A.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Encapsulated Salvia officinalis L. powder (SESP) was developed from extract obtained by supercritical fluid extraction (SFE), and it was compared with commercial sage powder of hydro-distillation extract (HESP). The optimised conditions of 30 MPa at 50 °C for laboratory scale SFE extraction were found to generate the highest yield at 40.96 ± 0.84%. The conditions were later applied in the upscaled extraction, which yielded about 30.10 ± 1.33% extract. Large particle size distribution at 118.46 ± 6.63 µm for SESP was notified as compared to 66.80 ± 1.50 µm for HESP. Outcomes of crystallographic analysis demonstrated that abundant metabolites from various groups existed in both powders. About 25 and 43 metabolites were identified by Gas Chromatography-Mass Spectrometry (GC–MS) in HESP and SESP, respectively. In HESP, organic acids were found to be the major group identified, while terpenoids were the largest group found in SESP.

AB - Encapsulated Salvia officinalis L. powder (SESP) was developed from extract obtained by supercritical fluid extraction (SFE), and it was compared with commercial sage powder of hydro-distillation extract (HESP). The optimised conditions of 30 MPa at 50 °C for laboratory scale SFE extraction were found to generate the highest yield at 40.96 ± 0.84%. The conditions were later applied in the upscaled extraction, which yielded about 30.10 ± 1.33% extract. Large particle size distribution at 118.46 ± 6.63 µm for SESP was notified as compared to 66.80 ± 1.50 µm for HESP. Outcomes of crystallographic analysis demonstrated that abundant metabolites from various groups existed in both powders. About 25 and 43 metabolites were identified by Gas Chromatography-Mass Spectrometry (GC–MS) in HESP and SESP, respectively. In HESP, organic acids were found to be the major group identified, while terpenoids were the largest group found in SESP.

KW - L.

KW - Encapsulated sage extract powder

KW - Supercritical fluid extraction

KW - Hydro-distillation

KW - Encapsulation

KW - Metabolite

U2 - 10.1016/j.supflu.2022.105571

DO - 10.1016/j.supflu.2022.105571

M3 - Article

VL - 184

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

SN - 0896-8446

M1 - 105571

ER -