Dynamic developmental expression of smallminded, a Drosophila gene required for cell division

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Dynamic developmental expression of smallminded, a Drosophila gene required for cell division. / Long, Antony R.; Wilkins, Joanna C.; Shepherd, David.
Yn: Mechanisms of development, Cyfrol 76, Rhif 1-2, 08.1998, t. 33-43.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Long, AR, Wilkins, JC & Shepherd, D 1998, 'Dynamic developmental expression of smallminded, a Drosophila gene required for cell division', Mechanisms of development, cyfrol. 76, rhif 1-2, tt. 33-43. https://doi.org/10.1016/S0925-4773(98)00110-5

APA

Long, A. R., Wilkins, J. C., & Shepherd, D. (1998). Dynamic developmental expression of smallminded, a Drosophila gene required for cell division. Mechanisms of development, 76(1-2), 33-43. https://doi.org/10.1016/S0925-4773(98)00110-5

CBE

MLA

Long, Antony R., Joanna C. Wilkins a David Shepherd. "Dynamic developmental expression of smallminded, a Drosophila gene required for cell division". Mechanisms of development. 1998, 76(1-2). 33-43. https://doi.org/10.1016/S0925-4773(98)00110-5

VancouverVancouver

Long AR, Wilkins JC, Shepherd D. Dynamic developmental expression of smallminded, a Drosophila gene required for cell division. Mechanisms of development. 1998 Awst;76(1-2):33-43. doi: 10.1016/S0925-4773(98)00110-5

Author

Long, Antony R. ; Wilkins, Joanna C. ; Shepherd, David. / Dynamic developmental expression of smallminded, a Drosophila gene required for cell division. Yn: Mechanisms of development. 1998 ; Cyfrol 76, Rhif 1-2. tt. 33-43.

RIS

TY - JOUR

T1 - Dynamic developmental expression of smallminded, a Drosophila gene required for cell division

AU - Long, Antony R.

AU - Wilkins, Joanna C.

AU - Shepherd, David

N1 - Copyright 1998 Elsevier Science Ireland Ltd. All Rights Reserved.

PY - 1998/8

Y1 - 1998/8

N2 - Here we describe the expression pattern of the smallminded (smid) gene during Drosophila development and investigate the phenotype of a null mutant. In situ hybridisation reveals the ubiquitous expression of smid transcript throughout early embryonic stages until the extended germ band stage, after which expression becomes localised to the neurogenic ectoderm and gonad. Post-embryonic expression is restricted to tissues engaged in the developmental programme of the adult fly: the re-enlarged neuroblasts; imaginal disks; histoblast nests; and precursors of adult muscles. The correlation of smid expression with mitotic activity suggests a cell cycle function which is confirmed by the observed phenotype of a smid null mutant characterised by an abnormally small CNS, due to defective mitosis of post-embryonic neuroblasts and their subsequent death by apoptosis.

AB - Here we describe the expression pattern of the smallminded (smid) gene during Drosophila development and investigate the phenotype of a null mutant. In situ hybridisation reveals the ubiquitous expression of smid transcript throughout early embryonic stages until the extended germ band stage, after which expression becomes localised to the neurogenic ectoderm and gonad. Post-embryonic expression is restricted to tissues engaged in the developmental programme of the adult fly: the re-enlarged neuroblasts; imaginal disks; histoblast nests; and precursors of adult muscles. The correlation of smid expression with mitotic activity suggests a cell cycle function which is confirmed by the observed phenotype of a smid null mutant characterised by an abnormally small CNS, due to defective mitosis of post-embryonic neuroblasts and their subsequent death by apoptosis.

KW - Animals

KW - Bromodeoxyuridine/metabolism

KW - Cell Cycle Proteins/genetics

KW - Cell Death

KW - Cell Division/genetics

KW - Drosophila/embryology

KW - Drosophila Proteins

KW - Embryo, Nonmammalian

KW - Gene Expression Regulation, Developmental

KW - In Situ Hybridization

KW - In Situ Nick-End Labeling

KW - Larva

KW - Mutation

KW - Neurons/physiology

U2 - 10.1016/S0925-4773(98)00110-5

DO - 10.1016/S0925-4773(98)00110-5

M3 - Article

C2 - 9767094

VL - 76

SP - 33

EP - 43

JO - Mechanisms of development

JF - Mechanisms of development

SN - 0925-4773

IS - 1-2

ER -