Fersiynau electronig


  • David Gillespie
    School of Healthcare Sciences, Cardiff University
  • Fiona Wood
    School of Healthcare Sciences, Cardiff University
  • Adam Williams
    School of Healthcare Sciences, Cardiff University
  • Richard Ma
    Grand Challenges in Ecosystem and the Environment Initiative, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK alexander.papadopulos@plants.ox.ac.uk.
  • Marijn de Bruin
    Radboud University Medical Center
  • Dyfrig Hughes
  • Adam T. Jones
    Public Health Wales NHS Trust
  • Zoë Couzens
    Public Health Wales NHS Trust
  • Kerenza Hood
    South East Wales Trials Unit, Cardiff University
Introduction: HIV pre-exposure prophylaxis (PrEP) involves the use of antiretroviral medication in HIV-negative individuals considered to be at risk of acquiring HIV. It has been shown to prevent HIV and has been available in Wales since July 2017. Measuring and understanding adherence to PrEP is complex as it relies on the simultaneous understanding of both PrEP use and sexual activity. We aimed to understand the experiences of men who have sex with men (MSM) living in Wales initiating, implementing, and persisting with HIV PrEP.
Methods: We conducted semi-structured interviews with MSM PrEP users in Wales who participated in a cohort study of PrEP use and sexual behaviour. Following completion of the cohort study, participants were invited to take part in a semi-structured interview about their experiences of taking PrEP. We aimed to include both individuals who had persisted with and discontinued PrEP during the study. The interview topic guide was informed by the ABC taxonomy for medication adherence and the theory of planned behaviour. We analysed our data using reflexive thematic analysis.
Results: 21 participants were interviewed, five having discontinued PrEP during the cohort study. The developed themes focused on triggers for initiating PrEP, habitual behaviour, drivers for discontinuation, and engagement with sexual health services. Stigma surrounding both PrEP and HIV permeated most topics, acting as a driver for initiating PrEP, an opportunity to reduce discrimination against people living with HIV, but also a concern around the perception of PrEP users.
Conclusion: This is the first study to investigate PrEP taking experiences incorporating established medication adherence taxonomy. We highlight key experiences regarding the initiation, implementation, and persistence with PrEP and describe how taking PrEP may promote positive engagement with sexual health services. These findings may be useful for informing PrEP rollout programmes and need exploring in other key populations.
Patient and public contribution
PrEP users, in addition to PrEP providers and representatives of HIV advocacy and policy were involved in developing the topic guide for this study.


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StatwsWedi ei Dderbyn / Yn y wasg - 12 Ion 2022
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