Fear-Specific Amygdala Function in Children and Adolescents on the Fragile X Spectrum: A Dosage Response of the FMR1 Gene
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Fersiynau electronig
Dangosydd eitem ddigidol (DOI)
Mutations of the fragile X mental retardation 1 (FMR1) gene are the
genetic cause of fragile X syndrome (FXS). The presence of signifi-
cant socioemotional problems has been well documented in FXS
although the brain basis of those deficits remains unspecified. Here,
we investigated amygdala dysfunction and its relation to socioemotional
deficits and FMR1 gene expression in children and adolescents
on the FX spectrum (i.e., individuals whose trinucleotide CGG
repeat expansion from 55 to over 200 places them somewhere
within the fragile X diagnostic range from premutation to full
mutation). Participants performed an fMRI task in which they
viewed fearful, happy, and scrambled faces. Neuroimaging results
demonstrated that FX participants revealed significantly attenuated
amygdala activation in Fearful > Scrambled and Fearful > Happy
contrasts compared with their neurotypical counterparts, while
showing no differences in amygdala volume. Furthermore, we found
significant relationships between FMR1 gene expression, anxiety/
social dysfunction scores, and reduced amygdala activation in the
FX group. In conclusion, we report novel evidence regarding a
dosage response of the FMR1 gene on fear-specific functions of the
amygdala, which is associated with socioemotional deficits in FXS
Iaith wreiddiol | Saesneg |
---|---|
Tudalennau (o-i) | 600-613 |
Cyfnodolyn | Cerebral Cortex |
Cyfrol | 24 |
Rhif y cyfnodolyn | 3 |
Dyddiad ar-lein cynnar | 11 Tach 2012 |
Dynodwyr Gwrthrych Digidol (DOIs) | |
Statws | Cyhoeddwyd - Maw 2014 |