Functional neurochemical imaging of the human striatal cholinergic system during reversal learning
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: European Journal of Neuroscience, Cyfrol 47, Rhif 10, 23.05.2018, t. 1184-1193.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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TY - JOUR
T1 - Functional neurochemical imaging of the human striatal cholinergic system during reversal learning
AU - Bell, Tiffany
AU - Lindner, Michael
AU - Mullins, Paul Gerald
AU - Christakou, Anastasia
N1 - Funding Information Human Frontier Science Program. Grant Number: RGP0048/2012 Engineering and Physical Sciences Research Council. Grant Number: EP/L505043/1
PY - 2018/5/23
Y1 - 2018/5/23
N2 - Animal studies have shown that acetylcholine (ACh) levels in the dorsal striatum play a role in reversal learning. However, this has not been studied in humans due to a lack of appropriate non-invasive techniques. Proton magnetic resonance spectroscopy (1 H-MRS) can be used to measure metabolite levels in humans in vivo. Although it cannot be used to study ACh directly, 1 H-MRS can be used to study choline, an ACh precursor which is linked to activity-dependent ACh release. The aim of this study was to use functional-1 H-MRS (fMRS) to measure changes in choline levels in the human dorsal striatum during performance of a probabilistic reversal learning task. We demonstrate a task-dependent decrease in choline, specifically during reversal, but not initial, learning. We interpret this to reflect a sustained increase in ACh levels, which is in line with findings from the animal literature. This task-dependent change was specific to choline and was not observed in control metabolites. These findings provide support for the use of fMRS in the in vivo study of the human cholinergic system. This article is protected by copyright. All rights reserved.
AB - Animal studies have shown that acetylcholine (ACh) levels in the dorsal striatum play a role in reversal learning. However, this has not been studied in humans due to a lack of appropriate non-invasive techniques. Proton magnetic resonance spectroscopy (1 H-MRS) can be used to measure metabolite levels in humans in vivo. Although it cannot be used to study ACh directly, 1 H-MRS can be used to study choline, an ACh precursor which is linked to activity-dependent ACh release. The aim of this study was to use functional-1 H-MRS (fMRS) to measure changes in choline levels in the human dorsal striatum during performance of a probabilistic reversal learning task. We demonstrate a task-dependent decrease in choline, specifically during reversal, but not initial, learning. We interpret this to reflect a sustained increase in ACh levels, which is in line with findings from the animal literature. This task-dependent change was specific to choline and was not observed in control metabolites. These findings provide support for the use of fMRS in the in vivo study of the human cholinergic system. This article is protected by copyright. All rights reserved.
KW - Journal Article
KW - choline
KW - Magnetic Resonance Spectroscopy
KW - Reversal Learning
KW - Striatum
UR - https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejn.13803&file=ejn13803-sup-0001-reviewer_comments.pdf
U2 - 10.1111/ejn.13803
DO - 10.1111/ejn.13803
M3 - Article
C2 - 29265530
VL - 47
SP - 1184
EP - 1193
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 10
ER -