Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Joshua C Tremblay
    Queen's University
  • Ryan L Hoiland
    University of British Columbia, Okanagan
  • Connor A Howe
    University of British Columbia, Okanagan
  • Geoff B Coombs
    University of British Columbia, Okanagan
  • Gustavo A Vizcardo-Galindo
    Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
  • Rómulo J Figueroa-Mujíca
    Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
  • Daniela Bermudez
    Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
  • Travis D Gibbons
    University of Otago
  • Benjamin S Stacey
    University of South Wales
  • Damian M Bailey
    University of South Wales
  • Michael M Tymko
    University of British Columbia, Okanagan
  • David B MacLeod
    Duke University Medical Center
  • Chris Gasho
    Loma Linda University School of Medicine
  • Francisco C Villafuerte
    Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
  • Kyra E Pyke
    Queen's University
  • Philip N Ainslie
    University of British Columbia, Okanagan

Excessive erythrocytosis (EE; hemoglobin concentration [Hb] ≥21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated dilation (FMD) in male Andeans with and without EE. We hypothesized that FMD would be impaired in Andeans with EE after accounting for shear stress and that FMD would improve after isovolemic hemodilution. Brachial artery shear stress and FMD were assessed in 23 male Andeans without EE (age: 40±15 years [mean±SD]; Hb<21 g/dL) and 19 male Andeans with EE (age: 43±14 years; Hb≥21 g/dL) in Cerro de Pasco, Peru (4330 m). Shear stress was quantified from Duplex ultrasound measures of shear rate and blood viscosity. In a subset of participants (n=8), FMD was performed before and after isovolemic hemodilution with blood volume replaced by an equal volume of human serum albumin. Blood viscosity and Hb were 48% and 23% higher (both P<0.001) and FMD was 28% lower after adjusting for the shear stress stimulus ( P=0.013) in Andeans with EE compared to those without. FMD was inversely correlated with blood viscosity ( r2=0.303; P<0.001) and Hb ( r2=0.230; P=0.001). Isovolemic hemodilution decreased blood viscosity by 30±10% and Hb by 14±5% (both P<0.001) and improved shear stress stimulus-adjusted FMD from 2.7±1.9% to 4.3±1.9% ( P=0.022). Hyperviscosity, high Hb, or both, actively contribute to acutely reversible impairments in FMD in EE, suggesting that this plays a pathogenic role in the increased cardiovascular risk.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)1327-1335
Nifer y tudalennau9
CyfnodolynHypertension (Dallas, Tex. : 1979)
Cyfrol73
Rhif y cyfnodolyn6
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Meh 2019
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau