TY - JOUR

T1 - Graded and sharp transitions in semantic function in left temporal lobe

AU - Krieger-Redwood, Katya

AU - Wang, Xiuyi

AU - Souter, Nicholas

AU - Gonzalez Alam, Tirso

AU - Smallwood, Jonathan

AU - Jackson, Rebecca L.

AU - Jefferies, Elizabeth

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Recent work has focussed on how patterns of functional change within the temporal lobe relate to whole-brain dimensions of intrinsic connectivity variation (Margulies et al., 2016). We examined two such ‘connectivity gradients’ reflecting the separation of (i) unimodal versus heteromodal and (ii) visual versus auditory-motor cortex, examining visually presented verbal associative and feature judgments, plus picture-based context and emotion generation. Functional responses along the first dimension sometimes showed graded change between modality-tuned and heteromodal cortex (in the verbal matching task), and other times showed sharp functional transitions, with deactivation at the extremes and activation in the middle of this gradient (internal generation). The second gradient revealed more visual than auditory-motor activation, regardless of content (associative, feature, context, emotion) or task process (matching/generation). We also uncovered subtle differences across each gradient for content type, which predominantly manifested as differences in relative magnitude of activation or deactivation.

AB - Recent work has focussed on how patterns of functional change within the temporal lobe relate to whole-brain dimensions of intrinsic connectivity variation (Margulies et al., 2016). We examined two such ‘connectivity gradients’ reflecting the separation of (i) unimodal versus heteromodal and (ii) visual versus auditory-motor cortex, examining visually presented verbal associative and feature judgments, plus picture-based context and emotion generation. Functional responses along the first dimension sometimes showed graded change between modality-tuned and heteromodal cortex (in the verbal matching task), and other times showed sharp functional transitions, with deactivation at the extremes and activation in the middle of this gradient (internal generation). The second gradient revealed more visual than auditory-motor activation, regardless of content (associative, feature, context, emotion) or task process (matching/generation). We also uncovered subtle differences across each gradient for content type, which predominantly manifested as differences in relative magnitude of activation or deactivation.

U2 - 10.1016/j.bandl.2024.105402

DO - 10.1016/j.bandl.2024.105402

M3 - Article

VL - 251

JO - Brain and Language

JF - Brain and Language

SN - 0093-934X

M1 - 105402

ER -