Highs and lows of hyperoxia: physiological, performance, and clinical aspects

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Highs and lows of hyperoxia: physiological, performance, and clinical aspects. / Brugniaux, Julien Vincent; Coombs, Geoff B; Barak, Otto F et al.
Yn: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Cyfrol 315, Rhif 1, 01.07.2018, t. R1-R27.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl adolyguadolygiad gan gymheiriaid

HarvardHarvard

Brugniaux, JV, Coombs, GB, Barak, OF, Dujic, Z, Sekhon, MS & Ainslie, PN 2018, 'Highs and lows of hyperoxia: physiological, performance, and clinical aspects', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, cyfrol. 315, rhif 1, tt. R1-R27. https://doi.org/10.1152/ajpregu.00165.2017

APA

Brugniaux, J. V., Coombs, G. B., Barak, O. F., Dujic, Z., Sekhon, M. S., & Ainslie, P. N. (2018). Highs and lows of hyperoxia: physiological, performance, and clinical aspects. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 315(1), R1-R27. https://doi.org/10.1152/ajpregu.00165.2017

CBE

Brugniaux JV, Coombs GB, Barak OF, Dujic Z, Sekhon MS, Ainslie PN. 2018. Highs and lows of hyperoxia: physiological, performance, and clinical aspects. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315(1):R1-R27. https://doi.org/10.1152/ajpregu.00165.2017

MLA

Brugniaux, Julien Vincent et al. "Highs and lows of hyperoxia: physiological, performance, and clinical aspects". American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2018, 315(1). R1-R27. https://doi.org/10.1152/ajpregu.00165.2017

VancouverVancouver

Brugniaux JV, Coombs GB, Barak OF, Dujic Z, Sekhon MS, Ainslie PN. Highs and lows of hyperoxia: physiological, performance, and clinical aspects. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2018 Gor 1;315(1):R1-R27. doi: 10.1152/ajpregu.00165.2017

Author

Brugniaux, Julien Vincent ; Coombs, Geoff B ; Barak, Otto F et al. / Highs and lows of hyperoxia : physiological, performance, and clinical aspects. Yn: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2018 ; Cyfrol 315, Rhif 1. tt. R1-R27.

RIS

TY - JOUR

T1 - Highs and lows of hyperoxia

T2 - physiological, performance, and clinical aspects

AU - Brugniaux, Julien Vincent

AU - Coombs, Geoff B

AU - Barak, Otto F

AU - Dujic, Zeljko

AU - Sekhon, Mypinder S

AU - Ainslie, Philip N

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Molecular oxygen (O2) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content ([Formula: see text]), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds, including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Nevertheless, with various degrees of effectiveness, and not without consequences, supplemental oxygen is used clinically in an attempt to correct tissue hypoxia (e.g., brain ischemia, traumatic brain injury, carbon monoxide poisoning, etc.) and chronic hypoxemia (e.g., severe COPD, etc.) and to help with wound healing, necrosis, or reperfusion injuries (e.g., compromised grafts). Hyperoxia has also been used liberally by athletes in a belief that it offers performance-enhancing benefits; such benefits also extend to hypoxemic patients both at rest and during rehabilitation. This review aims to provide a comprehensive overview of the effects of hyperoxia in humans from the "bench to bedside." The first section will focus on the basic physiological principles of partial pressure of arterial O2, [Formula: see text], and barometric pressure and how these changes lead to variation in regional O2 delivery. This review provides an overview of the evidence for and against the use of hyperoxia as an aid to enhance physical performance. The final section addresses pathophysiological concepts, clinical studies, and implications for therapy. The potential of O2 toxicity and future research directions are also considered.

AB - Molecular oxygen (O2) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content ([Formula: see text]), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds, including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Nevertheless, with various degrees of effectiveness, and not without consequences, supplemental oxygen is used clinically in an attempt to correct tissue hypoxia (e.g., brain ischemia, traumatic brain injury, carbon monoxide poisoning, etc.) and chronic hypoxemia (e.g., severe COPD, etc.) and to help with wound healing, necrosis, or reperfusion injuries (e.g., compromised grafts). Hyperoxia has also been used liberally by athletes in a belief that it offers performance-enhancing benefits; such benefits also extend to hypoxemic patients both at rest and during rehabilitation. This review aims to provide a comprehensive overview of the effects of hyperoxia in humans from the "bench to bedside." The first section will focus on the basic physiological principles of partial pressure of arterial O2, [Formula: see text], and barometric pressure and how these changes lead to variation in regional O2 delivery. This review provides an overview of the evidence for and against the use of hyperoxia as an aid to enhance physical performance. The final section addresses pathophysiological concepts, clinical studies, and implications for therapy. The potential of O2 toxicity and future research directions are also considered.

KW - Administration, Inhalation

KW - Animals

KW - Athletic Performance

KW - Biomarkers/blood

KW - Exercise Tolerance

KW - Hemodynamics

KW - Humans

KW - Hyperoxia/blood

KW - Lung/physiopathology

KW - Oxygen/administration & dosage

KW - Partial Pressure

KW - Pulmonary Ventilation

KW - Regional Blood Flow

KW - Risk Assessment

KW - Vasoconstriction

U2 - 10.1152/ajpregu.00165.2017

DO - 10.1152/ajpregu.00165.2017

M3 - Review article

C2 - 29488785

VL - 315

SP - R1-R27

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

SN - 0363-6119

IS - 1

ER -