Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration. / Owen, Julian A.; Fortes, Matthew B.; Ur Rahman, Saeed et al.
Yn: International Journal of Sport Nutrition and Exercise Metabolism, Cyfrol 29, Rhif 6, 11.2019, t. 604-611.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Owen, JA, Fortes, MB, Ur Rahman, S, Jibani, M, Walsh, NP & Oliver, SJ 2019, 'Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration', International Journal of Sport Nutrition and Exercise Metabolism, cyfrol. 29, rhif 6, tt. 604-611. https://doi.org/10.1123/ijsnem.2019-0022

APA

Owen, J. A., Fortes, M. B., Ur Rahman, S., Jibani, M., Walsh, N. P., & Oliver, S. J. (2019). Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration. International Journal of Sport Nutrition and Exercise Metabolism, 29(6), 604-611. https://doi.org/10.1123/ijsnem.2019-0022

CBE

Owen JA, Fortes MB, Ur Rahman S, Jibani M, Walsh NP, Oliver SJ. 2019. Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration. International Journal of Sport Nutrition and Exercise Metabolism. 29(6):604-611. https://doi.org/10.1123/ijsnem.2019-0022

MLA

VancouverVancouver

Owen JA, Fortes MB, Ur Rahman S, Jibani M, Walsh NP, Oliver SJ. Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration. International Journal of Sport Nutrition and Exercise Metabolism. 2019 Tach;29(6):604-611. Epub 2019. doi: 10.1123/ijsnem.2019-0022

Author

Owen, Julian A. ; Fortes, Matthew B. ; Ur Rahman, Saeed et al. / Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration. Yn: International Journal of Sport Nutrition and Exercise Metabolism. 2019 ; Cyfrol 29, Rhif 6. tt. 604-611.

RIS

TY - JOUR

T1 - Hydration marker diagnostic accuracy to identify mild intracellular and extracellular dehydration

AU - Owen, Julian A.

AU - Fortes, Matthew B.

AU - Ur Rahman, Saeed

AU - Jibani, Mahdi

AU - Walsh, Neil P.

AU - Oliver, Samuel J.

PY - 2019/11

Y1 - 2019/11

N2 - Identifying mild dehydration (≤2% of body mass) is important to prevent the negative effects of more severe dehydration on human health and performance. It is unknown whether a single hydration marker can identify both mild intracellular and extracellular dehydration with adequate diagnostic accuracy (≥0.7 receiver operating characteristic-area under the curve (ROC-AUC)). Thus, in 15 young healthy men, we determined the diagnostic accuracy of 15 hydration markers after three randomized 48-h trials; euhydration (EU, water 36 ml·kg·d-1), intracellular dehydration caused by exercise and 48 h of fluid restriction (ID, water 2 ml·kg·d-1), and extracellular dehydration caused by a 4 h diuretic-induced diuresis, begun at 44 h (ED, Furosemide 0.65 mg·kg-1). Body mass was maintained on EU and dehydration was mild on ID and ED (1.9 (0.5)% and 2.0 (0.3)% of body mass, respectively). Urine color, urine specific gravity, plasma osmolality, saliva flow rate, saliva osmolality, heart rate variability and dry mouth identified ID (ROC-AUC; range 0.70-0.99) and postural heart rate change identified ED (ROC-AUC 0.82). Thirst 0-9 scale (ROC-AUC 0.97 and 0.78 for ID and ED) and urine osmolality (ROC-AUC 0.99 and 0.81 for ID and ED) identified both dehydration types. However, only thirst 0-9 scale had a common dehydration threshold (≥4; sensitivity and specificity of 100%, 87% and 71%, 87% for ID and ED). In conclusion, using a common dehydration threshold ≥4, the thirst 0-9 scale identified mild intracellular and extracellular dehydration with adequate diagnostic accuracy. In young healthy adults’ thirst 0-9 scale is a valid and practical dehydration-screening tool.

AB - Identifying mild dehydration (≤2% of body mass) is important to prevent the negative effects of more severe dehydration on human health and performance. It is unknown whether a single hydration marker can identify both mild intracellular and extracellular dehydration with adequate diagnostic accuracy (≥0.7 receiver operating characteristic-area under the curve (ROC-AUC)). Thus, in 15 young healthy men, we determined the diagnostic accuracy of 15 hydration markers after three randomized 48-h trials; euhydration (EU, water 36 ml·kg·d-1), intracellular dehydration caused by exercise and 48 h of fluid restriction (ID, water 2 ml·kg·d-1), and extracellular dehydration caused by a 4 h diuretic-induced diuresis, begun at 44 h (ED, Furosemide 0.65 mg·kg-1). Body mass was maintained on EU and dehydration was mild on ID and ED (1.9 (0.5)% and 2.0 (0.3)% of body mass, respectively). Urine color, urine specific gravity, plasma osmolality, saliva flow rate, saliva osmolality, heart rate variability and dry mouth identified ID (ROC-AUC; range 0.70-0.99) and postural heart rate change identified ED (ROC-AUC 0.82). Thirst 0-9 scale (ROC-AUC 0.97 and 0.78 for ID and ED) and urine osmolality (ROC-AUC 0.99 and 0.81 for ID and ED) identified both dehydration types. However, only thirst 0-9 scale had a common dehydration threshold (≥4; sensitivity and specificity of 100%, 87% and 71%, 87% for ID and ED). In conclusion, using a common dehydration threshold ≥4, the thirst 0-9 scale identified mild intracellular and extracellular dehydration with adequate diagnostic accuracy. In young healthy adults’ thirst 0-9 scale is a valid and practical dehydration-screening tool.

U2 - 10.1123/ijsnem.2019-0022

DO - 10.1123/ijsnem.2019-0022

M3 - Article

VL - 29

SP - 604

EP - 611

JO - International Journal of Sport Nutrition and Exercise Metabolism

JF - International Journal of Sport Nutrition and Exercise Metabolism

SN - 1526-484X

IS - 6

ER -