Fersiynau electronig


Dangosydd eitem ddigidol (DOI)

  • Peter Fonagy
    University College London
  • Rabih El Chammay
    Ministry of Public Health Lebanon
  • Carol Ngunu
    Nairobi City County Government
  • Manasi Kumar
    University of Washington-Kenya, Nairobi
  • Lena Verdeli
    Columbia University, New York
  • Elizabeth Allison
    University College London
  • Ghida Anani
  • Pasco Fearon
    University College London
  • Fouad Fouad
    American University of Beirut
  • Zoe Hoare
  • Lucina Koyio
    Nairobi City County Government
  • Henrietta Moore
    University College London
  • Andrew Nyandigisi
    Health Strat
  • Stephen Pilling
    University College London
  • Hannah Sender
    University College London
  • Jolene Skordis
    University College London
  • Rachel Evans
  • Gerard Joseph Abou Jaoude
    University College London
  • Beatrice Madeghe
    University of Washington-Kenya, Nairobi
  • Sandra Pardi Arsen Maradian
    Ministry of Public Health Lebanon
  • Ciara O'Donnell
    University College London
  • Elizabeth Simes
    University College London
  • Alexandra Truscott
    University College London
  • Grace Nduku Wambua
    University of Washington-Kenya, Nairobi
  • Obadia Yator
    University of Washington-Kenya, Nairobi

BACKGROUND: Depression ranks as the foremost mental health concern among childbearing women. Within low- and middle-income countries (LMICs), between 20 and 25% of women encounter depression during pregnancy or soon after delivery. This condition impacts not only the mothers but also their offspring. Offspring of women suffering from postnatal depression (PND) exhibit suboptimal cognitive development and increased emotional and behavioural issues throughout their growth. This scenario becomes more pronounced in LMICs, where numerous adversities further jeopardise children's developmental progress. Despite antenatal services providing a pivotal platform to address women's mental health needs, PND treatment remains inaccessible in many LMICs. The World Health Organization advocates interpersonal psychotherapy (IPT) for treating depression. While research from high-income countries has established the efficacy of IPT and group-IPT (g-IPT) for PND, its effectiveness within the LMIC context and its potential benefits for child development remain uncharted. This study seeks to gauge the potency of g-IPT for women with PND in two LMICs.

METHODS: This multi-site randomised controlled trial is a continuation of two preceding phases-conceptual mapping and a feasibility study executed in Lebanon and Kenya. Insights gleaned from these phases underpin this comprehensive RCT, which contrasts the efficacy and cost-effectiveness of high-quality standard care (HQ-SC) augmented with g-IPT against HQ-SC in isolation. The trial, characterised as an individually randomised superiority assessment, targets women with postnatal depression in Beirut, Lebanon, and Nairobi, Kenya. It aims to determine if culturally tailored g-IPT, administered within community settings in both countries, outperforms HQ-SC in influencing child developmental outcomes, maternal depression, and the quality of the mother-child bond.

DISCUSSION: The SUMMIT trial, designed with pragmatism, possesses the magnitude to evaluate g-IPT within two LMIC frameworks. It seeks to enlighten policymakers, service commissioners, professionals, and users about g-IPT's potential to alleviate maternal PND and bolster child developmental outcomes in LMICs. Additionally, the trial will generate valuable data on the clinical and economic merits of high-quality standard care.

TRIAL REGISTRATION: ISRCTN, ISRCTN15154316. Registered on 27 September 2023, https://doi.org/10.1186/ISRCTN15154316.


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Rhif yr erthygl217
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Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 26 Maw 2024
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