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Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial). / Clare, Linda ; Kudlicka, Aleksandra; Oyebode, J.R. et al.
Yn: International Journal of Geriatric Psychiatry, Cyfrol 34, Rhif 5, 05.2019, t. 709-721.

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HarvardHarvard

Clare, L, Kudlicka, A, Oyebode, JR, Jones, RW, Bayer, A, Leroi, I, Kopelman, M, James, I, Culverwell, A, Pool, J, Brand, A, Henderson, C, Hoare, Z, Knapp, M & Woods, R 2019, 'Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial)', International Journal of Geriatric Psychiatry, cyfrol. 34, rhif 5, tt. 709-721. https://doi.org/10.1002/gps.5076

APA

Clare, L., Kudlicka, A., Oyebode, J. R., Jones, R. W., Bayer, A., Leroi, I., Kopelman, M., James, I., Culverwell, A., Pool, J., Brand, A., Henderson, C., Hoare, Z., Knapp, M., & Woods, R. (2019). Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial). International Journal of Geriatric Psychiatry, 34(5), 709-721. https://doi.org/10.1002/gps.5076

CBE

Clare L, Kudlicka A, Oyebode JR, Jones RW, Bayer A, Leroi I, Kopelman M, James I, Culverwell A, Pool J, et al. 2019. Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial). International Journal of Geriatric Psychiatry. 34(5):709-721. https://doi.org/10.1002/gps.5076

MLA

VancouverVancouver

Clare L, Kudlicka A, Oyebode JR, Jones RW, Bayer A, Leroi I et al. Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial). International Journal of Geriatric Psychiatry. 2019 Mai;34(5):709-721. Epub 2019 Chw 6. doi: 10.1002/gps.5076

Author

Clare, Linda ; Kudlicka, Aleksandra ; Oyebode, J.R. et al. / Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial). Yn: International Journal of Geriatric Psychiatry. 2019 ; Cyfrol 34, Rhif 5. tt. 709-721.

RIS

TY - JOUR

T1 - Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: a multi-centre randomised controlled trial (the GREAT trial)

AU - Clare, Linda

AU - Kudlicka, Aleksandra

AU - Oyebode, J.R.

AU - Jones, Roy W

AU - Bayer, A.

AU - Leroi, Iracema

AU - Kopelman, M.

AU - James, Ian

AU - Culverwell, Alison

AU - Pool, J.

AU - Brand, Andrew

AU - Henderson, Catherine

AU - Hoare, Zoe

AU - Knapp, Martin

AU - Woods, Robert

N1 - National Institute for Health, Health Technology Assessment Programme, Grant/Award Number: 11/15/04 © 2019 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.

PY - 2019/5

Y1 - 2019/5

N2 - ObjectivesTo determine whether individual goal‐oriented cognitive rehabilitation (CR) improves everyday functioning for people with mild‐to‐moderate dementia.Design and methodsParallel group multicentre single‐blind randomised controlled trial (RCT) comparing CR added to usual treatment (CR) with usual treatment alone (TAU) for people with an ICD‐10 diagnosis of Alzheimer, vascular or mixed dementia, and mild‐to‐moderate cognitive impairment (Mini‐Mental State Examination [MMSE] score ≥ 18), and with a family member willing to contribute. Participants allocated to CR received 10 weekly sessions over 3 months and four maintenance sessions over 6 months. Participants were followed up 3 and 9 months post randomisation by blinded researchers. The primary outcome was self‐reported goal attainment at 3 months. Secondary outcomes at 3 and 9 months included informant‐reported goal attainment, quality of life, mood, self‐efficacy, and cognition and study partner stress and quality of life.ResultsWe randomised (1:1) 475 people with dementia; 445 (CR = 281) were included in the intention to treat analysis at 3 months and 426 (CR = 208) at 9 months. At 3 months, there were statistically significant large positive effects for participant‐rated goal attainment (d = 0.97; 95% CI, 0.75‐1.19), corroborated by informant ratings (d = 1.11; 95% CI, 0.89‐1.34). These effects were maintained at 9 months for both participant (d = 0.94; 95% CI, 0.71‐1.17) and informant (d = 0.96; 95% CI, 0.73‐1.2) ratings. The observed gains related to goals directly targeted in the therapy. There were no significant differences in secondary outcomes.ConclusionsCR enables people with early‐stage dementia to improve their everyday functioning in relation to individual goals targeted in the therapy.

AB - ObjectivesTo determine whether individual goal‐oriented cognitive rehabilitation (CR) improves everyday functioning for people with mild‐to‐moderate dementia.Design and methodsParallel group multicentre single‐blind randomised controlled trial (RCT) comparing CR added to usual treatment (CR) with usual treatment alone (TAU) for people with an ICD‐10 diagnosis of Alzheimer, vascular or mixed dementia, and mild‐to‐moderate cognitive impairment (Mini‐Mental State Examination [MMSE] score ≥ 18), and with a family member willing to contribute. Participants allocated to CR received 10 weekly sessions over 3 months and four maintenance sessions over 6 months. Participants were followed up 3 and 9 months post randomisation by blinded researchers. The primary outcome was self‐reported goal attainment at 3 months. Secondary outcomes at 3 and 9 months included informant‐reported goal attainment, quality of life, mood, self‐efficacy, and cognition and study partner stress and quality of life.ResultsWe randomised (1:1) 475 people with dementia; 445 (CR = 281) were included in the intention to treat analysis at 3 months and 426 (CR = 208) at 9 months. At 3 months, there were statistically significant large positive effects for participant‐rated goal attainment (d = 0.97; 95% CI, 0.75‐1.19), corroborated by informant ratings (d = 1.11; 95% CI, 0.89‐1.34). These effects were maintained at 9 months for both participant (d = 0.94; 95% CI, 0.71‐1.17) and informant (d = 0.96; 95% CI, 0.73‐1.2) ratings. The observed gains related to goals directly targeted in the therapy. There were no significant differences in secondary outcomes.ConclusionsCR enables people with early‐stage dementia to improve their everyday functioning in relation to individual goals targeted in the therapy.

KW - Activities of Daily Living

KW - Alzheimer Disease

KW - Disability

KW - Goal-setting

KW - Nonpharmacological intervention

KW - Person-centred

KW - Problem Solving

KW - reablement

KW - vascular dementia

U2 - 10.1002/gps.5076

DO - 10.1002/gps.5076

M3 - Article

VL - 34

SP - 709

EP - 721

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 5

ER -