Household survey, focus group discussions, participatory rural appraisal (PRA) tools, viz, trend analyses for temperature, rainfall intensity and farming, pair wise ranking and matrix ranking to get people's perceptions and experiences on climate change in the Pokhare Khola watershed in the Middle-Hills of Nepal. Moreover, local meteorological data was analyzed to see the trend of changes in rainfall and temperature. Analyses of both Indigenous farmers' perceptions and meteorological data showed an increase of temperature with longer summers and warmer and shorter winter during the period of 1982-2007. There was a decreasing trend of rainfall over the years in an erratic and unpredictable manner. Water shortage, disease and pest infestation in crops and soil fertility loss are seen as major climate risks and hazards. Marginal and small groups of farmers are more vulnerable with low ability to cope with climate hazards due to lack of familiarity with these conditions. In order to adapt to these adverse conditions (trend of increased temperature and decreased rainfall), people's increasing tendency to apply chemical fertilizer instead of manure and practice less water demanded vegetables farming while decreasing trend of cereal farming was apparent in trend analysis of farming. The conversion of kharbari (grass production for roofing thatch and livestock feed) to barren wasteland and grass shortage caused the reduction in production of large livestock. The reduction in number of large livestock (cattle) due to fodder shortage results in less available manure and increased need for fertilizing and pesticide applications against disease, pest attacks and invasive species in crops induced loss of soil fertility for long term. The presence of mosquitoes was seen all year-round except it was only found during summer in the past.