TY - JOUR

T1 - Integrative crosstalk between hypoxia and the cold: old data and new opportunities

AU - Mugele, Hendrik

AU - Oliver, Sam

AU - Gagnon, Daniel

AU - Lawley, Justin

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Cold stress and hypoxia have been the subject of research for decades; however, humans often encounter these stressors together, such as in the alpine environment. Therefore, this review summarizes previous data with respect to the influence of hypoxia on thermoregulatory and cardiovascular control in the cold and presents new ideas for the future. Altogether, little to no evidence is available on the integrative and adaptive mechanisms about how the human body regulates heat conservation, oxygen delivery, and maintenance of blood pressure.

AB - Cold stress and hypoxia have been the subject of research for decades; however, humans often encounter these stressors together, such as in the alpine environment. Therefore, this review summarizes previous data with respect to the influence of hypoxia on thermoregulatory and cardiovascular control in the cold and presents new ideas for the future. Altogether, little to no evidence is available on the integrative and adaptive mechanisms about how the human body regulates heat conservation, oxygen delivery, and maintenance of blood pressure.

KW - cardiovascular physiology

KW - cold and hypoxia

KW - cutaneous vasoconstriction

KW - thermogenesis

U2 - 10.1113/EP088512

DO - 10.1113/EP088512

M3 - Article

VL - 106

SP - 350

EP - 358

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 1

ER -