TY - JOUR

T1 - Label-free non-invasive subwavelength-resolution imaging using yeast cells as biological lenses

AU - Jiang, Chunlei

AU - Yue, Hanyu

AU - Yan, Bing

AU - Dong, Taiji

AU - Cui, Xiangyu

AU - Chen, Peng

AU - Wang, Zengbo

N1 - © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - There is a growing interest to use live cells to replace the widely used non-biological microsphere lenses. In this work, we demonstrate the use of yeast cells for such imaging purpose. Using fiber-based optical trapping technique, we trap a chain of three yeast cells and bring them to the vicinity of imaging objects. These yeast cells work as near-field magnifying lenses and simultaneously pick up the sub-diffraction information of the nanoscale objects under each cell and project them into the far-field. The experimental results demonstrated that Blu-ray disc of 100 nm feature can be clearly resolved in a parallel manner by each cell.

AB - There is a growing interest to use live cells to replace the widely used non-biological microsphere lenses. In this work, we demonstrate the use of yeast cells for such imaging purpose. Using fiber-based optical trapping technique, we trap a chain of three yeast cells and bring them to the vicinity of imaging objects. These yeast cells work as near-field magnifying lenses and simultaneously pick up the sub-diffraction information of the nanoscale objects under each cell and project them into the far-field. The experimental results demonstrated that Blu-ray disc of 100 nm feature can be clearly resolved in a parallel manner by each cell.

U2 - 10.1364/BOE.437965

DO - 10.1364/BOE.437965

M3 - Article

C2 - 34858703

VL - 12

SP - 7113

EP - 7121

JO - Biomedical optics express

JF - Biomedical optics express

SN - 2156-7085

IS - 11

ER -