Fersiynau electronig

Dogfennau

Dangosydd eitem ddigidol (DOI)

  • Leonardo M S Mesquita
    São Paulo State University
  • Caroline F B Rodrigues
    São Paulo State University
  • Claudia Q da Rocha
    São Paulo State University
  • May Silveira Bianchim
    Federal University of Sao Paulo
  • Clenilson M Rodrigues
    Embrapa Agroenergy
  • Vanda M de Oliveira
    Embrapa Agroenergy
  • Henrique H Gaeta
    São Paulo State University
  • Mariana N Belchor
    São Paulo State University
  • Marcos H Toyama
    São Paulo State University
  • Wagner Vilegas
    São Paulo State University
We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)–ESI–IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]–FIA–IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3). The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series: one based on polymers of m/z 288 Da increments (up to DP12) and another series based on polymers of m/z [288 + 162] Da increments (up to DP11). In addition to these series of flavan-3-ol, each DP had a subset of masses with a variation of − 16 Da (homologous series of afzelechins—m/z 873–3465 Da) and + 16 Da (homologous series of gallocatechins—m/z 905–3497 Da). A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series: glucogallocatechins (m/z 779–3371) and glucoafzelechins (m/z 747–3339). The intraperitoneal administration of different doses of AERM (50, 150 and 300 µg mL−1) have a morphine-like effect and intense anti-inflammatory activity.
Iaith wreiddiolSaesneg
Tudalennau (o-i)23-34
CyfnodolynNatural Products and Bioprospecting
Cyfrol9
Dyddiad ar-lein cynnar14 Tach 2018
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Chwef 2019
Cyhoeddwyd yn allanolIe

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