Porth Ymchwil

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Brianne M Bettcher
    University of California, San Francisco
  • Ryan Fitch
    University of California, San Francisco
  • Matthew J Wynn
    University of California, San Francisco
  • Matthew A Lalli
    University of California, Santa Barbara
  • Jonathan Elofson
    University of California, San Francisco
  • Laura Jastrzab
    University of California, San Francisco
  • Laura Mitic
    University of California, San Francisco
  • Zachary A Miller
    University of California, San Francisco
  • Gil D Rabinovici
    University of California, San Francisco
  • Bruce L Miller
    University of California, San Francisco
  • Aimee W Kao
    University of California, San Francisco
  • Kenneth S Kosik
    University of California, Santa Barbara
  • Joel H Kramer
    University of California, San Francisco

INTRODUCTION: MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.

METHODS: MCP-1 and eotaxin-1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained.

RESULTS: An interaction was noted between MCP-1 and eotaxin-1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non-chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains.

DISCUSSION: These results suggest a potentially selective role for MCP-1 and eotaxin-1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

Iaith wreiddiolSaesneg
Tudalennau (o-i)91-7
Nifer y tudalennau7
CyfnodolynAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Cyfrol3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 22 Meh 2016
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau