The aim of the study was to estimate quality of life and determine the adjusted association of migraine with the quality of life in a sample of students. This population-based study was performed among 857 high school students in Boukan City (with a Kurdish language-speaking population, about 600 km west of the city of Tehran, Iran). The World Health Organization Quality of Life questionnaire was used along with International Headache Society criteria. Multiple linear regression models were applied. The mean scores of quality of life domains of physical health, psychological, environmental, and social relationships were 69.1 (standard deviation = 16.5), 61.5 (standard deviation = 18. 1), 66.3 (standard deviation = 20. 8), and 65.2 (standard deviation = 17. 8) out of 100, respectively. Migraine after adjusting for the other factors was associated significantly with the scores in the physical (P = .002), social (P = .002), and environmental (P = .033) domains. Migraine is associated with reducing the physical, environmental, and social aspects of the students' quality of life.