Mindfulness-Based Cognitive Therapy for Preventing Relapse in Recurrent Depression: A Randomized Dismantling Trial

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • J. Mark G. Williams
    University of Oxford
  • Catherine Crane
    University of Oxford
  • Thorsten Barnhofer
    University of Oxford
  • Kate Brennan
    University of Oxford
  • Danielle Duggan
    University of Oxford
  • Melanie Fennell
    University of Oxford
  • Ann Hackmann
    University of Oxford
  • Adele Krusche
    University of Oxford
  • Kate Muse
    University of Oxford
  • I.R. Von Rohr
    University of Oxford
  • Dhruvi Shah
    University of Oxford
  • Rebecca Crane
  • Catrin Eames
  • Mariel Jones
  • Sholto Radford
  • Sarah Silverton
  • Yongzhong Sun
  • Elaine Weatherley-Jones
  • Christopher Whitaker
  • Daphne Russell
    Swansea University
  • Ian Russell
    Swansea University
Objective: We compared mindfulness-based cognitive therapy (MBCT) with both cognitive psychological education (CPE) and treatment as usual (TAU) in preventing relapse to major depressive disorder (MDD) in people currently in remission following at least 3 previous episodes. Method: A randomized controlled trial in which 274 participants were allocated in the ratio 2:2:1 to MBCT plus TAU, CPE plus TAU, and TAU alone, and data were analyzed for the 255 (93%; MBCT = 99, CPE = 103, TAU = 53) retained to follow-up. MBCT was delivered in accordance with its published manual, modified to address suicidal cognitions; CPE was modeled on MBCT, but without training in meditation. Both treatments were delivered through 8 weekly classes. Results: Allocated treatment had no significant effect on risk of relapse to MDD over 12 months follow-up, hazard ratio for MBCT vs. CPE = 0.88, 95% CI [0.58, 1.35]; for MBCT vs. TAU = 0.69, 95% CI [0.42, 1.12]. However, severity of childhood trauma affected relapse, hazard ratio for increase of 1 standard deviation = 1.26 (95% CI [1.05, 1.50]), and significantly interacted with allocated treatment. Among participants above median severity, the hazard ratio was 0.61, 95% CI [0.34, 1.09], for MBCT vs. CPE, and 0.43, 95% CI [0.22, 0.87], for MBCT vs. TAU. For those below median severity, there were no such differences between treatment groups. Conclusion: MBCT provided significant protection against relapse for participants with increased vulnerability due to history of childhood trauma, but showed no significant advantage in comparison to an active control treatment and usual care over the whole group of patients with recurrent depression
Iaith wreiddiolSaesneg
Tudalennau (o-i)275-286
CyfnodolynJournal of Consulting and Clinical Psychology
Cyfrol82
Rhif y cyfnodolyn2
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2 Rhag 2013
Gweld graff cysylltiadau