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Dangosydd eitem ddigidol (DOI)

  • Kesey Yetsko
    University of Florida
  • Jessica Farrell
    University of Florida
  • Nicholas B. Blackburn
    University of Tasmania
  • Liam Whitmore
    University of Florida
  • Maximilian R. Stammnitz
    University of Cambridge
  • Jenny Whilde
    University of Florida
  • Catherine Eastman
    University of Florida
  • Devon Rollinson Ramia
    University of Florida
  • Rachel Thomas
    University of Florida
  • Aleksandar Krstic
    University College Dublin
  • Paul Linser
    University of Florida
  • Simon Creer
  • Gary Carvalho
  • Mariana A. Devlin
    Sea Turtle Inc
  • Nina Nahvi
    Sea Turtle Inc
  • Anna Cristina Leandro
    University of Texas Rio Grande Valley
  • Thomas W. deMaar
    Gladys Porter Zoo, Texas
  • Brooke Burkhalter
    University of Florida
  • Elizabeth P. Murchison
    University of Cambridge
  • Christine Schnitzler
    University of Florida, Gainesville
  • David Duffy
    University of Florida
Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression.

Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially therapeutically targetable molecular vulnerabilities in common, such as the MAPK, Wnt, TGFβ and TNF oncogenic signaling pathways. These conserved oncogenic drivers recapitulate remarkably well the core pan-cancer drivers responsible for human cancers. Fibropapillomatosis has been considered benign, but metastatic-related transcriptional signatures are strongly activated in kidney and established external tumors. Tumors in turtles with poor outcomes (died/euthanized) have genes associated with apoptosis and immune function suppressed, with these genes providing putative predictive biomarkers.

Together, these results offer an improved understanding of fibropapillomatosis tumorigenesis and provide insights into the origins, inter-tumor relationships, and therapeutic treatment for this wildlife epizootic.
Iaith wreiddiolSaesneg
Rhif yr erthygl152
CyfnodolynCommunications Biology
Cyfrol4
Rhif y cyfnodolyn1
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Chwef 2021

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