TY - JOUR

T1 - Nonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception

AU - Sturgeon, John A

AU - Tieu, Meghan M

AU - Jastrzab, Laura

AU - McCue, Rebecca

AU - Gandhi, Vanisha

AU - Mackey, Sean C

N1 - Wiley Periodicals, Inc.

PY - 2015/7/15

Y1 - 2015/7/15

N2 - OBJECTIVE: A bidirectional relationship between working memory (WM) and acute pain has long been assumed, but equivocal evidence exists regarding this relationship. This study characterized the relationship between WM and acute pain processing in healthy individuals using an adapted Sternberg WM task.DESIGN: Participants completed a Sternberg task while receiving noxious thermal stimulation. Participants received a pseudorandom presentation of four different temperatures (baseline temperatures and individually determined low-, medium-, and high-temperature stimuli) and four levels of Sternberg task difficulty (0-, 3-, 6-, and 9-letter strings).SUBJECTS: Twenty-eight healthy participants were recruited from Stanford University and the surrounding community to complete this study.RESULTS: A nonlinear interaction between intensity of thermal stimulation and difficulty of the Sternberg task was noted. Increased cognitive load from the Sternberg task resulted in increased perception of pain in low-intensity thermal stimulation but suppressed pain perception in high-intensity thermal stimulation. Thermal stimulation had no significant effect on participants' response time or accuracy on the Sternberg task regardless of intensity level.CONCLUSIONS: Pain perception appears to decrease as a function of WM load only for sufficiently noxious stimuli. However, increasing noxious stimuli did not affect cognitive performance. These complex relationships may reflect a shared cognitive space that can become "overloaded" with input of multiple stimuli of sufficient intensity.

AB - OBJECTIVE: A bidirectional relationship between working memory (WM) and acute pain has long been assumed, but equivocal evidence exists regarding this relationship. This study characterized the relationship between WM and acute pain processing in healthy individuals using an adapted Sternberg WM task.DESIGN: Participants completed a Sternberg task while receiving noxious thermal stimulation. Participants received a pseudorandom presentation of four different temperatures (baseline temperatures and individually determined low-, medium-, and high-temperature stimuli) and four levels of Sternberg task difficulty (0-, 3-, 6-, and 9-letter strings).SUBJECTS: Twenty-eight healthy participants were recruited from Stanford University and the surrounding community to complete this study.RESULTS: A nonlinear interaction between intensity of thermal stimulation and difficulty of the Sternberg task was noted. Increased cognitive load from the Sternberg task resulted in increased perception of pain in low-intensity thermal stimulation but suppressed pain perception in high-intensity thermal stimulation. Thermal stimulation had no significant effect on participants' response time or accuracy on the Sternberg task regardless of intensity level.CONCLUSIONS: Pain perception appears to decrease as a function of WM load only for sufficiently noxious stimuli. However, increasing noxious stimuli did not affect cognitive performance. These complex relationships may reflect a shared cognitive space that can become "overloaded" with input of multiple stimuli of sufficient intensity.

KW - Acute Pain/physiopathology

KW - Adolescent

KW - Adult

KW - Cognition

KW - Female

KW - Hot Temperature/adverse effects

KW - Humans

KW - Male

KW - Memory, Short-Term

KW - Neuropsychological Tests

KW - Nonlinear Dynamics

KW - Pain Measurement

KW - Pain Perception/physiology

KW - Reaction Time/physiology

KW - Young Adult

U2 - 10.1111/pme.12774

DO - 10.1111/pme.12774

M3 - Article

C2 - 25929747

VL - 16

SP - 1301

EP - 1310

JO - Pain Medicine

JF - Pain Medicine

SN - 1526-2375

IS - 7

ER -