On the ancestral recruitment of metalloproteinases into the venom of snakes
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Toxicon, Cyfrol 60, Rhif 4, 15.09.2012, t. 449-454.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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TY - JOUR
T1 - On the ancestral recruitment of metalloproteinases into the venom of snakes
AU - Casewell, N.R.
PY - 2012/9/15
Y1 - 2012/9/15
N2 - Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.
AB - Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.
U2 - 10.1016/j.toxicon.2012.02.006
DO - 10.1016/j.toxicon.2012.02.006
M3 - Article
VL - 60
SP - 449
EP - 454
JO - Toxicon
JF - Toxicon
SN - 0041-0101
IS - 4
ER -