On the ancestral recruitment of metalloproteinases into the venom of snakes

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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On the ancestral recruitment of metalloproteinases into the venom of snakes. / Casewell, N.R.
Yn: Toxicon, Cyfrol 60, Rhif 4, 15.09.2012, t. 449-454.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Casewell NR. On the ancestral recruitment of metalloproteinases into the venom of snakes. Toxicon. 2012 Medi 15;60(4):449-454. doi: 10.1016/j.toxicon.2012.02.006

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Casewell, N.R. / On the ancestral recruitment of metalloproteinases into the venom of snakes. Yn: Toxicon. 2012 ; Cyfrol 60, Rhif 4. tt. 449-454.

RIS

TY - JOUR

T1 - On the ancestral recruitment of metalloproteinases into the venom of snakes

AU - Casewell, N.R.

PY - 2012/9/15

Y1 - 2012/9/15

N2 - Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

AB - Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

U2 - 10.1016/j.toxicon.2012.02.006

DO - 10.1016/j.toxicon.2012.02.006

M3 - Article

VL - 60

SP - 449

EP - 454

JO - Toxicon

JF - Toxicon

SN - 0041-0101

IS - 4

ER -