Palaeogenome reveals genetic contribution of extinct giant panda to extant populations.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Dangosydd eitem ddigidol (DOI)

  • Guilian Sheng
    China University of Geosciences, Wuhan
  • Nikolas Basler
    University of Potsdam
  • Xueping Ji
    Yunnan Cultural Relics and Archaeology Institute
  • Johanna Paijmans
    University of Potsdam
  • Federica Alberti
    University of Potsdam
  • Michaela Preick
    University of Potsdam
  • Stefanie Hartmann
    University of Potsdam
  • Michael V. Westbury
    University of Potsdam
  • Junxia Yuan
    China University of Geosciences, Wuhan
  • Nina G. Jablonski
    Pennsylvania State University
  • Georgios Xenikoudakis
    University of Potsdam
  • Xindong Hou
    China University of Geosciences, Wuhan
  • Bo Xiao
    China University of Geosciences, Wuhan
  • Jian-Hui Liu
    Yunnan Cultural Relics and Archaeology Institute
  • Michael Hofreiter
    University of Potsdam
  • Xulong Lai
    China University of Geosciences, Wuhan
  • Axel Barlow
    University of Potsdam
Historically, the giant panda was widely distributed from northern China to southwestern Asia [1]. As a result of range contraction and fragmentation, extant individuals are currently restricted to fragmented mountain ranges on the eastern margin of the Qinghai-Tibet plateau, where they are distributed among three major population clusters [2]. However, little is known about the genetic consequences of this dramatic range contraction. For example, were regions where giant pandas previously existed occupied by ancestors of present-day populations, or were these regions occupied by genetically distinct populations that are now extinct? If so, is there any contribution of these extinct populations to the genomes of giant pandas living today? To investigate these questions, we sequenced the nuclear genome of an ∼5,000-year-old giant panda from Jiangdongshan, Tengchong County in Yunnan Province, China. We find that this individual represents a genetically distinct population that diverged prior to the diversification of modern giant panda populations. We find evidence of differential admixture with this ancient population among modern individuals originating from different populations as well as within the same population. We also find evidence for directional gene flow, which transferred alleles from the ancient population into the modern giant panda lineages. A variable proportion of the genomes of extant individuals is therefore likely derived from the ancient population represented by our sequenced individual. Although extant giant panda populations retain reasonable genetic diversity, our results suggest that this represents only part of the genetic diversity this species harbored prior to its recent range contractions.
Iaith wreiddiolSaesneg
Tudalennau (o-i)1695-1700
CyfnodolynCurrent Biology
Cyfrol29
Rhif y cyfnodolyn10
Dyddiad ar-lein cynnar9 Mai 2019
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 20 Mai 2019
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau