TY - JOUR

T1 - Parkinson's disease -the debate on the clinical phenomenology, aetiology, pathology and pathogenesis

AU - Jenner, Peter

AU - Morris, Huw R

AU - Robbins, Trevor W

AU - Goedert, Michel

AU - Hardy, John

AU - Ben-Shlomo, Yoav

AU - Bolam, Paul

AU - Burn, David

AU - Hindle, John V

AU - Brooks, David

PY - 2013

Y1 - 2013

N2 - The definition of Parkinson's disease (PD) is changing with the expansion of clinical phenomenology and improved understanding of environmental and genetic influences that impact on the pathogenesis of the disease at the cellular and molecular level. This had led to debate and discussion with as yet, no general acceptance of the direction that change should take either at the level of diagnosis or of what should and should not be sheltered under an umbrella of PD. This article is one contribution to this on-going discussion. There are two different themes running through the article--widening the definition of PD/LBD/synucleinopathies and the heterogeneity that exists within PD itself from a clinical, pathological and genetic perspective. The conclusion reached is that in the future, further diagnostic categories will need to be recognized. These are likely to include--Parkinson's syndrome, Parkinson's syndrome likely to be Lewy body PD, clinical PD (defined by QSBB criteria), Lewy body disease (PD, LBD, REM SBD) and synucleinopathies (including LBD, MSA).

AB - The definition of Parkinson's disease (PD) is changing with the expansion of clinical phenomenology and improved understanding of environmental and genetic influences that impact on the pathogenesis of the disease at the cellular and molecular level. This had led to debate and discussion with as yet, no general acceptance of the direction that change should take either at the level of diagnosis or of what should and should not be sheltered under an umbrella of PD. This article is one contribution to this on-going discussion. There are two different themes running through the article--widening the definition of PD/LBD/synucleinopathies and the heterogeneity that exists within PD itself from a clinical, pathological and genetic perspective. The conclusion reached is that in the future, further diagnostic categories will need to be recognized. These are likely to include--Parkinson's syndrome, Parkinson's syndrome likely to be Lewy body PD, clinical PD (defined by QSBB criteria), Lewy body disease (PD, LBD, REM SBD) and synucleinopathies (including LBD, MSA).

KW - Cognition Disorders

KW - Early Diagnosis

KW - Heterozygote

KW - Humans

KW - Lewy Body Disease

KW - Mutation

KW - Parkinson Disease

KW - Psychomotor Disorders

KW - Synucleins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.3233/JPD-130175

DO - 10.3233/JPD-130175

M3 - Review article

C2 - 23938306

VL - 3

SP - 1

EP - 11

JO - Journal of Parkinson's disease

JF - Journal of Parkinson's disease

SN - 1877-7171

IS - 1

ER -