TY - JOUR

T1 - Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila

AU - Williams, Darren W.

AU - Shepherd, David

PY - 2002/2

Y1 - 2002/2

N2 - We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

AB - We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

KW - Animals

KW - Drosophila/cytology

KW - Larva/cytology

KW - Laser Therapy

KW - Nervous System/growth & development

KW - Neurons, Afferent/cytology

KW - Wings, Animal/innervation

M3 - Article

C2 - 11830563

VL - 129

SP - 617

EP - 624

JO - Development

JF - Development

SN - 0950-1991

IS - 3

ER -