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Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. / Greenwood, Sharlene A.; Koufaki, Pelagia; Macdonald, Jamie; Bhandari, Sunil; Burton, James O.; Dasgupta, Indranil; Farrington, Kenneth; Ford, Ian; Kalra, Philip A; Kean, Sharon; Kumwenda, Mick; Macdougall, Iain C; Messow, Claudia-Martina; Mitra, Sandip; Reid, Chante; Smith, Alice C; Taal, Maarten W; Thompson, Peter C.; Wheeler, David C; White, Claire; Yaqoob, Magdi; Mercer, Thomas.

Yn: Kidney International Reports, Cyfrol 6, Rhif 8, 01.08.2021, t. 2159-2170.

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HarvardHarvard

Greenwood, SA, Koufaki, P, Macdonald, J, Bhandari, S, Burton, JO, Dasgupta, I, Farrington, K, Ford, I, Kalra, PA, Kean, S, Kumwenda, M, Macdougall, IC, Messow, C-M, Mitra, S, Reid, C, Smith, AC, Taal, MW, Thompson, PC, Wheeler, DC, White, C, Yaqoob, M & Mercer, T 2021, 'Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis', Kidney International Reports, cyfrol. 6, rhif 8, tt. 2159-2170. https://doi.org/10.1016/j.ekir.2021.05.034

APA

Greenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J. O., Dasgupta, I., Farrington, K., Ford, I., Kalra, P. A., Kean, S., Kumwenda, M., Macdougall, I. C., Messow, C-M., Mitra, S., Reid, C., Smith, A. C., Taal, M. W., Thompson, P. C., Wheeler, D. C., ... Mercer, T. (2021). Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. Kidney International Reports, 6(8), 2159-2170. https://doi.org/10.1016/j.ekir.2021.05.034

CBE

Greenwood SA, Koufaki P, Macdonald J, Bhandari S, Burton JO, Dasgupta I, Farrington K, Ford I, Kalra PA, Kean S, Kumwenda M, Macdougall IC, Messow C-M, Mitra S, Reid C, Smith AC, Taal MW, Thompson PC, Wheeler DC, White C, Yaqoob M, Mercer T. 2021. Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. Kidney International Reports. 6(8):2159-2170. https://doi.org/10.1016/j.ekir.2021.05.034

MLA

VancouverVancouver

Greenwood SA, Koufaki P, Macdonald J, Bhandari S, Burton JO, Dasgupta I et al. Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. Kidney International Reports. 2021 Aug 1;6(8):2159-2170. https://doi.org/10.1016/j.ekir.2021.05.034

Author

Greenwood, Sharlene A. ; Koufaki, Pelagia ; Macdonald, Jamie ; Bhandari, Sunil ; Burton, James O. ; Dasgupta, Indranil ; Farrington, Kenneth ; Ford, Ian ; Kalra, Philip A ; Kean, Sharon ; Kumwenda, Mick ; Macdougall, Iain C ; Messow, Claudia-Martina ; Mitra, Sandip ; Reid, Chante ; Smith, Alice C ; Taal, Maarten W ; Thompson, Peter C. ; Wheeler, David C ; White, Claire ; Yaqoob, Magdi ; Mercer, Thomas. / Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. Yn: Kidney International Reports. 2021 ; Cyfrol 6, Rhif 8. tt. 2159-2170.

RIS

TY - JOUR

T1 - Randomized Trial-PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis

AU - Greenwood, Sharlene A.

AU - Koufaki, Pelagia

AU - Macdonald, Jamie

AU - Bhandari, Sunil

AU - Burton, James O.

AU - Dasgupta, Indranil

AU - Farrington, Kenneth

AU - Ford, Ian

AU - Kalra, Philip A

AU - Kean, Sharon

AU - Kumwenda, Mick

AU - Macdougall, Iain C

AU - Messow, Claudia-Martina

AU - Mitra, Sandip

AU - Reid, Chante

AU - Smith, Alice C

AU - Taal, Maarten W

AU - Thompson, Peter C.

AU - Wheeler, David C

AU - White, Claire

AU - Yaqoob, Magdi

AU - Mercer, Thomas

N1 - © 2021 International Society of Nephrology. Published by Elsevier Inc.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - IntroductionWhether clinically implementable exercise interventions in people receiving hemodialysis (HD) therapy improve health-related quality of life (HRQoL) remains unknown. The PrEscription of intraDialytic exercise to improve quAlity of Life (PEDAL) study evaluated the clinical benefit and cost-effectiveness of a 6-month intradialytic exercise program.MethodsIn a multicenter, single-blinded, randomized, controlled trial, people receiving HD were randomly assigned to (i) intradialytic exercise training (exercise intervention group [EX]) and (ii) usual care (control group [CON]). Primary outcome was change in Kidney Disease Quality of Life Short-Form Physical Component Summary (KDQOL-SF 1.3 PCS) from baseline to 6 months. Cost-effectiveness was determined using health economic analysis; physiological impairment was evaluated by peak oxygen uptake; and harms were recorded.ResultsWe randomized 379 participants; 335 and 243 patients (EX n = 127; CON n = 116) completed baseline and 6-month assessments, respectively. Mean difference in change PCS from baseline to 6 months between EX and CON was 2.4 (95% confidence interval [CI]: −0.1 to 4.8) arbitrary units (P = 0.055); no improvements were observed in peak oxygen uptake or secondary outcome measures. Participants in the intervention group had poor compliance (47%) and poor adherence (18%) to the exercise prescription. Cost of delivering intervention ranged from US$598 to US$1092 per participant per year. The number of participants with harms was similar between EX (n = 69) and CON (n = 56). A primary limitation was the lack of an attention CON. Many patients also withdrew from the study or were too unwell to complete all physiological outcome assessments.ConclusionsA 6-month intradialytic aerobic exercise program was not clinically beneficial in improving HRQoL as delivered to this cohort of deconditioned patients on HD.

AB - IntroductionWhether clinically implementable exercise interventions in people receiving hemodialysis (HD) therapy improve health-related quality of life (HRQoL) remains unknown. The PrEscription of intraDialytic exercise to improve quAlity of Life (PEDAL) study evaluated the clinical benefit and cost-effectiveness of a 6-month intradialytic exercise program.MethodsIn a multicenter, single-blinded, randomized, controlled trial, people receiving HD were randomly assigned to (i) intradialytic exercise training (exercise intervention group [EX]) and (ii) usual care (control group [CON]). Primary outcome was change in Kidney Disease Quality of Life Short-Form Physical Component Summary (KDQOL-SF 1.3 PCS) from baseline to 6 months. Cost-effectiveness was determined using health economic analysis; physiological impairment was evaluated by peak oxygen uptake; and harms were recorded.ResultsWe randomized 379 participants; 335 and 243 patients (EX n = 127; CON n = 116) completed baseline and 6-month assessments, respectively. Mean difference in change PCS from baseline to 6 months between EX and CON was 2.4 (95% confidence interval [CI]: −0.1 to 4.8) arbitrary units (P = 0.055); no improvements were observed in peak oxygen uptake or secondary outcome measures. Participants in the intervention group had poor compliance (47%) and poor adherence (18%) to the exercise prescription. Cost of delivering intervention ranged from US$598 to US$1092 per participant per year. The number of participants with harms was similar between EX (n = 69) and CON (n = 56). A primary limitation was the lack of an attention CON. Many patients also withdrew from the study or were too unwell to complete all physiological outcome assessments.ConclusionsA 6-month intradialytic aerobic exercise program was not clinically beneficial in improving HRQoL as delivered to this cohort of deconditioned patients on HD.

KW - rehabilitation

KW - Physical activity

KW - Chronic Kidney Disease

KW - Physical Function

U2 - 10.1016/j.ekir.2021.05.034

DO - 10.1016/j.ekir.2021.05.034

M3 - Article

C2 - 34386665

VL - 6

SP - 2159

EP - 2170

JO - Kidney International Reports

JF - Kidney International Reports

SN - 2468-0249

IS - 8

ER -