Rapid Y degeneration and dosage compensation in plant sex chromosomes

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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Rapid Y degeneration and dosage compensation in plant sex chromosomes. / Papadopulos, Alexander S T; Chester, Michael; Ridout, Kate et al.
Yn: Proceedings of the National Academy of Sciences of the United States of America, Cyfrol 112, Rhif 42, 20.10.2015, t. 13021-6.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Papadopulos, AST, Chester, M, Ridout, K & Filatov, DA 2015, 'Rapid Y degeneration and dosage compensation in plant sex chromosomes', Proceedings of the National Academy of Sciences of the United States of America, cyfrol. 112, rhif 42, tt. 13021-6. https://doi.org/10.1073/pnas.1508454112

APA

Papadopulos, A. S. T., Chester, M., Ridout, K., & Filatov, D. A. (2015). Rapid Y degeneration and dosage compensation in plant sex chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(42), 13021-6. https://doi.org/10.1073/pnas.1508454112

CBE

Papadopulos AST, Chester M, Ridout K, Filatov DA. 2015. Rapid Y degeneration and dosage compensation in plant sex chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 112(42):13021-6. https://doi.org/10.1073/pnas.1508454112

MLA

Papadopulos, Alexander S T et al. "Rapid Y degeneration and dosage compensation in plant sex chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 2015, 112(42). 13021-6. https://doi.org/10.1073/pnas.1508454112

VancouverVancouver

Papadopulos AST, Chester M, Ridout K, Filatov DA. Rapid Y degeneration and dosage compensation in plant sex chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 2015 Hyd 20;112(42):13021-6. Epub 2015 Hyd 5. doi: 10.1073/pnas.1508454112

Author

Papadopulos, Alexander S T ; Chester, Michael ; Ridout, Kate et al. / Rapid Y degeneration and dosage compensation in plant sex chromosomes. Yn: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Cyfrol 112, Rhif 42. tt. 13021-6.

RIS

TY - JOUR

T1 - Rapid Y degeneration and dosage compensation in plant sex chromosomes

AU - Papadopulos, Alexander S T

AU - Chester, Michael

AU - Ridout, Kate

AU - Filatov, Dmitry A

PY - 2015/10/20

Y1 - 2015/10/20

N2 - The nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed to reveal large-scale gene degeneration on plant Y chromosomes. Here, we uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, that evolved sex chromosomes de novo in the last 10 million years. Previous transcriptome-based studies of this species missed unexpressed, degenerate Y-linked genes. To identify sex-linked genes, regardless of their expression, we sequenced male and female genomes of S. latifolia and integrated the genomic contigs with a high-density genetic map. This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupted by premature stop codons. This contrasts with X-linked genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in males. Loss of functional Y-linked genes is partly compensated for by gene-specific up-regulation of X-linked genes. Our results demonstrate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals, and that the evolutionary trajectories of sex chromosomes are similar in the two kingdoms.

AB - The nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed to reveal large-scale gene degeneration on plant Y chromosomes. Here, we uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, that evolved sex chromosomes de novo in the last 10 million years. Previous transcriptome-based studies of this species missed unexpressed, degenerate Y-linked genes. To identify sex-linked genes, regardless of their expression, we sequenced male and female genomes of S. latifolia and integrated the genomic contigs with a high-density genetic map. This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupted by premature stop codons. This contrasts with X-linked genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in males. Loss of functional Y-linked genes is partly compensated for by gene-specific up-regulation of X-linked genes. Our results demonstrate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals, and that the evolutionary trajectories of sex chromosomes are similar in the two kingdoms.

KW - Chromosomes, Plant

KW - Dosage Compensation, Genetic

KW - Genetic Linkage

KW - Plants

KW - Sex Chromosomes

KW - Silene

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - https://www.pnas.org/content/early/2015/09/30/1508454112/tab-figures-data

U2 - 10.1073/pnas.1508454112

DO - 10.1073/pnas.1508454112

M3 - Article

C2 - 26438872

VL - 112

SP - 13021

EP - 13026

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 42

ER -