Research needs for optimising wastewater-based epidemiology monitoring for public health protection

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

Fersiynau electronig


Dangosydd eitem ddigidol (DOI)

  • Katie Robins
    UK Health Security Agency
  • Anne F. C. Leonard
    UK Health Security Agency
  • Kata Farkas
  • David W. Graham
    Institute for Health and Society, Newcastle University, Newcastle upon Tyne, UK.
  • Barbara Kasprzyk-Hordern
    University of Bath
  • Joshua T. Bunce
    UK Health Security Agency
  • Jasmine M. S. Grimsley
    UK Health Security Agency
  • Matthew J. Wade
    UK Health Security Agency
  • Andrew M. Zealand
    UK Health Security Agency
  • Shannon McIntyre-Nolan
    UK Health Security Agency
  • Davey L. Jones
Wastewater-based epidemiology (WBE) is an unobtrusive method used to observe patterns in illicit drug use, poliovirus, and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The pandemic and need for surveillance measures have led to the rapid acceleration of WBE research and development globally. With the infrastructure available to monitor SARS-CoV-2 from wastewater in 58 countries globally, there is potential to expand targets and applications for public health protection, such as other viral pathogens, antimicrobial resistance (AMR), pharmaceutical consumption, or exposure to chemical pollutants. Some applications have been explored in academic research but are not used to inform public health decision-making. We reflect on the current knowledge of WBE for these applications and identify barriers and opportunities for expanding beyond SARS-CoV-2. This paper critically reviews the applications of WBE for public health and identifies the important research gaps for WBE to be a useful tool in public health. It considers possible uses for pathogenic viruses, AMR, and chemicals. It summarises the current evidence on the following: (1) the presence of markers in stool and urine; (2) environmental factors influencing persistence of markers in wastewater; (3) methods for sample collection and storage; (4) prospective methods for detection and quantification; (5) reducing uncertainties; and (6) further considerations for public health use.


Iaith wreiddiolSaesneg
Tudalennau (o-i)1284-1313
CyfnodolynJournal of Water and Health
Rhif y cyfnodolyn9
Dyddiad ar-lein cynnar12 Awst 2022
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Medi 2022

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