TY - JOUR

T1 - Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

AU - Duffy, David J.

AU - Schnitzler, Christine

AU - Karpinski, Lorraine

AU - Thomas, Rachel

AU - Whilde, Jenny

AU - Eastman, Catherine

AU - Yang, Calvin

AU - Krstic, Aleksandar

AU - Rollinson, Devon

AU - Zirkelbach, Bette

AU - Yetsko, Kesey

AU - Burkhalter, Brooke

AU - Martindale, Mark Q,

PY - 2018/6/7

Y1 - 2018/6/7

N2 - Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are required to help maintain healthy populations until the chronic underlying causes of these issues can be addressed. Fibropapillomatosis in sea turtles is one such wildlife disease. Here, we applied precision-medicine-based approaches to profile fibropapillomatosis tumors to better understand their biology, identify novel therapeutics, and gain insights into viral and environmental triggers for fibropapillomatosis. We show that fibropapillomatosis tumors share genetic vulnerabilities with human cancer types, revealing that they are amenable to treatment with human anti-cancer therapeutics

AB - Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are required to help maintain healthy populations until the chronic underlying causes of these issues can be addressed. Fibropapillomatosis in sea turtles is one such wildlife disease. Here, we applied precision-medicine-based approaches to profile fibropapillomatosis tumors to better understand their biology, identify novel therapeutics, and gain insights into viral and environmental triggers for fibropapillomatosis. We show that fibropapillomatosis tumors share genetic vulnerabilities with human cancer types, revealing that they are amenable to treatment with human anti-cancer therapeutics

U2 - 10.1038/s42003-018-0059-x

DO - 10.1038/s42003-018-0059-x

M3 - Article

VL - 1

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

M1 - 63

ER -