Small airway patency in infants with apparent life-threatening events
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: European journal of pediatrics, Cyfrol 157, Rhif 1, 01.1998, t. 71-4.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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T1 - Small airway patency in infants with apparent life-threatening events
AU - Hartmann, H
AU - Seidenberg, J
AU - Noyes, J P
AU - O'Brien, L
AU - Poets, C F
AU - Samuels, M P
AU - Southall, D P
PY - 1998/1
Y1 - 1998/1
N2 - UNLABELLED: A reduction in specific airway conductance has been reported in infants with a history of an apparent life-threatening event (ALTE). It is unclear, however, whether this reflects upper or lower airway narrowing. We performed a controlled study to determine small airway patency in infants with ALTE. Lung function tests were performed in 26 infants with a history of ALTE and 27 healthy controls. Partial expiratory flow-volume curves were obtained during quiet sleep using the rapid chest compression technique; thoracic gas volume (TGV) and expiratory airway resistance (RAW) were measured by whole body plethysmography. Compliance of the respiratory system (Crs) was measured using the single breath occlusion technique. The median maximal flow at functional residual capacity (VmaxFRC) was 85 ml/s (range 10-198 ml/s) in patients and 123 (range 47-316 ml/s) in controls (P = 0.003). VmaxFRC corrected for TGV was 0.5 s(-1) (range 0.06-1.3 s[-1]) and 0.9 s(-1) (range 0.4-1.8 s[-1]), respectively (P = 0.001). TGV, RAW and Crs were not significantly different between patients and controls.CONCLUSION: Reduced small airway patency may play a role in the pathogenesis of ALTE.
AB - UNLABELLED: A reduction in specific airway conductance has been reported in infants with a history of an apparent life-threatening event (ALTE). It is unclear, however, whether this reflects upper or lower airway narrowing. We performed a controlled study to determine small airway patency in infants with ALTE. Lung function tests were performed in 26 infants with a history of ALTE and 27 healthy controls. Partial expiratory flow-volume curves were obtained during quiet sleep using the rapid chest compression technique; thoracic gas volume (TGV) and expiratory airway resistance (RAW) were measured by whole body plethysmography. Compliance of the respiratory system (Crs) was measured using the single breath occlusion technique. The median maximal flow at functional residual capacity (VmaxFRC) was 85 ml/s (range 10-198 ml/s) in patients and 123 (range 47-316 ml/s) in controls (P = 0.003). VmaxFRC corrected for TGV was 0.5 s(-1) (range 0.06-1.3 s[-1]) and 0.9 s(-1) (range 0.4-1.8 s[-1]), respectively (P = 0.001). TGV, RAW and Crs were not significantly different between patients and controls.CONCLUSION: Reduced small airway patency may play a role in the pathogenesis of ALTE.
KW - Airway Obstruction
KW - Airway Resistance
KW - Analysis of Variance
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Respiratory Function Tests
KW - Respiratory Mechanics
KW - Sudden Infant Death
KW - Clinical Trial
KW - Controlled Clinical Trial
KW - Journal Article
U2 - 10.1007/s004310050770
DO - 10.1007/s004310050770
M3 - Article
C2 - 9461368
VL - 157
SP - 71
EP - 74
JO - European journal of pediatrics
JF - European journal of pediatrics
SN - 0340-6199
IS - 1
ER -