Structural Connectivity of the Developing Human Amygdala

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Structural Connectivity of the Developing Human Amygdala. / Saygin, Z.M.; Osher, D.E.; Koldewyn, K. et al.
Yn: PLoS ONE, Cyfrol 10, Rhif 4, 15.04.2015, t. 1-19.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Saygin, ZM, Osher, DE, Koldewyn, K, Martin, RE, Finn, A, Saxe, R, Gabrieli, JD & Sheridan, M 2015, 'Structural Connectivity of the Developing Human Amygdala', PLoS ONE, cyfrol. 10, rhif 4, tt. 1-19. https://doi.org/10.1371/journal.pone.0125170

APA

Saygin, Z. M., Osher, D. E., Koldewyn, K., Martin, R. E., Finn, A., Saxe, R., Gabrieli, J. D., & Sheridan, M. (2015). Structural Connectivity of the Developing Human Amygdala. PLoS ONE, 10(4), 1-19. https://doi.org/10.1371/journal.pone.0125170

CBE

Saygin ZM, Osher DE, Koldewyn K, Martin RE, Finn A, Saxe R, Gabrieli JD, Sheridan M. 2015. Structural Connectivity of the Developing Human Amygdala. PLoS ONE. 10(4):1-19. https://doi.org/10.1371/journal.pone.0125170

MLA

VancouverVancouver

Saygin ZM, Osher DE, Koldewyn K, Martin RE, Finn A, Saxe R et al. Structural Connectivity of the Developing Human Amygdala. PLoS ONE. 2015 Ebr 15;10(4):1-19. doi: 10.1371/journal.pone.0125170

Author

Saygin, Z.M. ; Osher, D.E. ; Koldewyn, K. et al. / Structural Connectivity of the Developing Human Amygdala. Yn: PLoS ONE. 2015 ; Cyfrol 10, Rhif 4. tt. 1-19.

RIS

TY - JOUR

T1 - Structural Connectivity of the Developing Human Amygdala

AU - Saygin, Z.M.

AU - Osher, D.E.

AU - Koldewyn, K.

AU - Martin, R.E.

AU - Finn, A.

AU - Saxe, R.

AU - Gabrieli, J.D.

AU - Sheridan, M.

PY - 2015/4/15

Y1 - 2015/4/15

N2 - A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus’ connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age.

AB - A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus’ connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age.

U2 - 10.1371/journal.pone.0125170

DO - 10.1371/journal.pone.0125170

M3 - Article

VL - 10

SP - 1

EP - 19

JO - PLoS ONE

JF - PLoS ONE

IS - 4

ER -