Structural Design of Robust and Biocompatible Photonic Hydrogels from an In Situ Cross-Linked Hyperbranched Polymer System
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Chemistry of Materials, Cyfrol 30, Rhif 17, 11.09.2018, t. 6091-6098.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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T1 - Structural Design of Robust and Biocompatible Photonic Hydrogels from an In Situ Cross-Linked Hyperbranched Polymer System
AU - Zhang, Jing
AU - Yong, Haiyang
AU - A, Sigen
AU - Xu, Qian
AU - Lyu, Jing
AU - Gao, Yongsheng
AU - Zeng, Ming
AU - Zhou, Dezhong
AU - Yu, Ziyi
AU - Tai, Hongyun
AU - Wang, Wenxin
PY - 2018/9/11
Y1 - 2018/9/11
N2 - Multifunctional hyperbranched poly(poly(ethylene glycol) diacrylate) (HB-PEGDA) polymers with well-defined composition, structure, and functionality are proposed in this work as photonic hydrogel scaffolds. By taking advantage of its unique transparency, low intrinsic viscosity, and high amount of vinyl groups, the HB-PEGDA can effectively penetrate inside the colloidal photonic crystal (CPC) substrate and be cross-linked with thiolated hyaluronic acid very quickly. This photonic hydrogel shows not only an unexpected protective effect to the untreated CPC substrate, but also nonswelling characteristics attributed to its relatively compacted network structure, which leads to robust structural integrity and credible, consistent optical performance under complex physiological conditions. Moreover, this photonic hydrogel shows good biocompatibility and can be easily modified to introduce specific functions (e.g., cell attachment), providing novel insights into the photonic hydrogel design toward diverse bio-optical applications.
AB - Multifunctional hyperbranched poly(poly(ethylene glycol) diacrylate) (HB-PEGDA) polymers with well-defined composition, structure, and functionality are proposed in this work as photonic hydrogel scaffolds. By taking advantage of its unique transparency, low intrinsic viscosity, and high amount of vinyl groups, the HB-PEGDA can effectively penetrate inside the colloidal photonic crystal (CPC) substrate and be cross-linked with thiolated hyaluronic acid very quickly. This photonic hydrogel shows not only an unexpected protective effect to the untreated CPC substrate, but also nonswelling characteristics attributed to its relatively compacted network structure, which leads to robust structural integrity and credible, consistent optical performance under complex physiological conditions. Moreover, this photonic hydrogel shows good biocompatibility and can be easily modified to introduce specific functions (e.g., cell attachment), providing novel insights into the photonic hydrogel design toward diverse bio-optical applications.
U2 - 10.1021/acs.chemmater.8b02542
DO - 10.1021/acs.chemmater.8b02542
M3 - Article
VL - 30
SP - 6091
EP - 6098
JO - Chemistry of Materials
JF - Chemistry of Materials
SN - 0897-4756
IS - 17
ER -