Synthesis of wax esters and related trehalose esters from Mycobacterium avium and other mycobacteria
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Tetrahedron, Cyfrol 72, Rhif 27-28, 07.07.2016, t. 3863-3876.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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T1 - Synthesis of wax esters and related trehalose esters from Mycobacterium avium and other mycobacteria
AU - Taher, Salam
AU - Al-Dulayymi, Juma'a R.
AU - Tima, H. Griesse
AU - Ali, Hanan M.
AU - Romano, Marta
AU - Baird, Mark
PY - 2016/7/7
Y1 - 2016/7/7
N2 - The synthesis of mycobacterial mycolic acid related wax esters and of their trehalose di- and mono-esters is described. The trehalose dimycolates (TDMs) synthesised activated bone marrow derived dendritic cells (BMDCs) in vitro more strongly than trehalose dibehenate or the trehalose monomycolates (TMMs). The inflammatory effects were similar to those of TDM from either a synthetic keto- or methoxy-mycolic acid, but somewhat stronger than those of a TDM from an α-mycolic acid. In vivo, the effects of one wax ester TDM were similar to those of the methoxy-MA and α-mycolic acid TDMs and trehalose dibehenate.
AB - The synthesis of mycobacterial mycolic acid related wax esters and of their trehalose di- and mono-esters is described. The trehalose dimycolates (TDMs) synthesised activated bone marrow derived dendritic cells (BMDCs) in vitro more strongly than trehalose dibehenate or the trehalose monomycolates (TMMs). The inflammatory effects were similar to those of TDM from either a synthetic keto- or methoxy-mycolic acid, but somewhat stronger than those of a TDM from an α-mycolic acid. In vivo, the effects of one wax ester TDM were similar to those of the methoxy-MA and α-mycolic acid TDMs and trehalose dibehenate.
U2 - 10.1016/j.tet.2016.05.004
DO - 10.1016/j.tet.2016.05.004
M3 - Article
VL - 72
SP - 3863
EP - 3876
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 27-28
ER -