Systems approaches to microbial communities and their functioning
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
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Yn: Current Opinion in Biotechnology, Cyfrol 21, Rhif 4, 08.2010, t. 532-8.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
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TY - JOUR
T1 - Systems approaches to microbial communities and their functioning
AU - Röling, Wilfred F M
AU - Ferrer, Manuel
AU - Golyshin, Peter N
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2010/8
Y1 - 2010/8
N2 - Recent advances in molecular microbial ecology and systems biology enhance insight into microbial community structure and functioning. They provide conceptual and technical bases for the translation of species-data and community-data into a model framework accounting for the functioning of and interactions between metabolic networks of species in multispecies environments. Function-directed and single cell-directed approaches supplement and improve metagenomics-derived community information. The topology of the metabolic network, reconstructed from a species' genome sequence, provides insight into its metabolic environments and interactions with other microorganisms. Progress in the theoretical and experimental analysis of flux through metabolic networks paves the way for their application at the community level, contributing to understanding of material flows between and within species and their resilience toward perturbations.
AB - Recent advances in molecular microbial ecology and systems biology enhance insight into microbial community structure and functioning. They provide conceptual and technical bases for the translation of species-data and community-data into a model framework accounting for the functioning of and interactions between metabolic networks of species in multispecies environments. Function-directed and single cell-directed approaches supplement and improve metagenomics-derived community information. The topology of the metabolic network, reconstructed from a species' genome sequence, provides insight into its metabolic environments and interactions with other microorganisms. Progress in the theoretical and experimental analysis of flux through metabolic networks paves the way for their application at the community level, contributing to understanding of material flows between and within species and their resilience toward perturbations.
KW - Genome, Bacterial
KW - Microbiology
KW - Systems Biology
U2 - 10.1016/j.copbio.2010.06.007
DO - 10.1016/j.copbio.2010.06.007
M3 - Review article
C2 - 20637597
VL - 21
SP - 532
EP - 538
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 4
ER -