TY - JOUR

T1 - Temporal sorting of neural components underlying phonological processing

AU - Thierry, G

AU - Boulanouar, K

AU - Kherif, F

AU - Ranjeva, J P

AU - Démonet, J F

PY - 1999/8/20

Y1 - 1999/8/20

N2 - Event-related haemodynamic responses (EHRs) were recorded in subjects performing phonological tasks to test whether distinguishable temporal involvement of corresponding neural components would show through. A sequence of activation leading from primary auditory cortices to premotor regions emerged in the fast repetition and the phoneme monitoring tasks used. EHRs peaked significantly earlier in Wernicke's area (phonological decoding) than in Broca's area, the left supramarginal gyrus and the precentral gyrus (phonological rehearsal). Moreover, the sensitivity of within cluster temporal gradients to the nature of the tasks indicated either sensory to association cortex synchronization for fast repetition or delayed analysis for phoneme monitoring. These results are consistent with previous findings on working memory and show that fMRI permits temporal tracking of cognitive activations.

AB - Event-related haemodynamic responses (EHRs) were recorded in subjects performing phonological tasks to test whether distinguishable temporal involvement of corresponding neural components would show through. A sequence of activation leading from primary auditory cortices to premotor regions emerged in the fast repetition and the phoneme monitoring tasks used. EHRs peaked significantly earlier in Wernicke's area (phonological decoding) than in Broca's area, the left supramarginal gyrus and the precentral gyrus (phonological rehearsal). Moreover, the sensitivity of within cluster temporal gradients to the nature of the tasks indicated either sensory to association cortex synchronization for fast repetition or delayed analysis for phoneme monitoring. These results are consistent with previous findings on working memory and show that fMRI permits temporal tracking of cognitive activations.

KW - Adult

KW - Analysis of Variance

KW - Evoked Potentials, Auditory

KW - Female

KW - Hemodynamics

KW - Humans

KW - Male

KW - Phonetics

KW - Reaction Time

KW - Reference Values

KW - Verbal Learning

KW - Clinical Trial

KW - Journal Article

M3 - Article

C2 - 10574376

VL - 10

SP - 2599

EP - 2603

JO - Neuroreport

JF - Neuroreport

SN - 0959-4965

IS - 12

ER -