TY - JOUR

T1 - The 2018 Global Research Expedition on Altitude-related Chronic Health (REACH) to Cerro de Pasco, Peru: An Experimental Overview

AU - Tymko, Michael M

AU - Hoiland, Ryan L

AU - Tremblay, Joshua C

AU - Stembridge, Mike

AU - Dawkins, Tony G

AU - Coombs, Geoff B

AU - Patrician, Alexander

AU - Howe, Connor A

AU - Gibbons, Travis D

AU - Moore, Jonathan P

AU - Simpson, Lydia L

AU - Steinback, Craig D

AU - Meah, Victoria L

AU - Stacey, Benjamin S

AU - Bailey, Damian M

AU - MacLeod, David B

AU - Gasho, Christopher

AU - Anholm, James D

AU - Bain, Anthony R

AU - Lawley, Justin S

AU - Villafuerte, Francisco C

AU - Vizcardo-Galindo, Gustavo

AU - Ainslie, Philip N

N1 - Funding Information: Canada Research Chair; Natural Sciences and Engineering Research Council of Canada. Grant Number: Doctoral Grant ; Royal Society Wolfson Research Fellowship. Grant Number: #WM170007 Royal Society International Exchanges Award. Grant Number: IES\R2\192137 Japan Society for the Promotion of Science. Grant Number: Research Fellowship (#JSPS/OF317)

PY - 2021/1

Y1 - 2021/1

N2 - In 2016, the international research team ‐ Global Research Expedition on Altitude‐related Chronic Health (REACH) ‐ was established and executed a high altitude research expedition to Nepal. The team consists of ∼45 students, principal investigators and physicians with the common objective of conducting experiments focused on high altitude adaptation in lowlanders, and highlanders with lifelong exposure to high altitude. In 2018, Global REACH traveled to Peru where we performed a series of experiments in the Andean highlanders. The experimental objectives, organization and characteristics, and key cohort data from Global REACH's latest research expedition are outlined herein. Herein, fifteen major studies are described that aimed to elucidate the physiological differences in high altitude acclimatization between lowlanders (n = 30) and Andean born highlanders with (n = 22) and without (n = 45) Excessive Erythrocytosis (EE). After baseline testing in Kelowna, BC, Canada (344 m), Global REACH travelled to Lima, Peru (∼80 m), and then ascended by automobile to Cerro de Pasco, Peru (∼4300 m) where experiments were conducted over 25 days. The core studies focused on elucidating the mechanism(s) governing cerebral and peripheral vascular function, cardiopulmonary regulation, exercise performance, and autonomic control. Despite encountering serious logistical challenges, each of the proposed studies were completed at both sea level and high altitude amounting to ∼780 study sessions and > 3000 hrs of experimental testing. Participant demographics and data related to acid‐base balance and exercise capacity are presented. The collective findings will contribute to our understanding of how lowlanders and Andean highlanders have adapted under high altitude stress.

AB - In 2016, the international research team ‐ Global Research Expedition on Altitude‐related Chronic Health (REACH) ‐ was established and executed a high altitude research expedition to Nepal. The team consists of ∼45 students, principal investigators and physicians with the common objective of conducting experiments focused on high altitude adaptation in lowlanders, and highlanders with lifelong exposure to high altitude. In 2018, Global REACH traveled to Peru where we performed a series of experiments in the Andean highlanders. The experimental objectives, organization and characteristics, and key cohort data from Global REACH's latest research expedition are outlined herein. Herein, fifteen major studies are described that aimed to elucidate the physiological differences in high altitude acclimatization between lowlanders (n = 30) and Andean born highlanders with (n = 22) and without (n = 45) Excessive Erythrocytosis (EE). After baseline testing in Kelowna, BC, Canada (344 m), Global REACH travelled to Lima, Peru (∼80 m), and then ascended by automobile to Cerro de Pasco, Peru (∼4300 m) where experiments were conducted over 25 days. The core studies focused on elucidating the mechanism(s) governing cerebral and peripheral vascular function, cardiopulmonary regulation, exercise performance, and autonomic control. Despite encountering serious logistical challenges, each of the proposed studies were completed at both sea level and high altitude amounting to ∼780 study sessions and > 3000 hrs of experimental testing. Participant demographics and data related to acid‐base balance and exercise capacity are presented. The collective findings will contribute to our understanding of how lowlanders and Andean highlanders have adapted under high altitude stress.

KW - Adaptation, Physiological/physiology

KW - Adult

KW - Altitude

KW - Altitude Sickness/physiopathology

KW - Chronic Disease

KW - Cohort Studies

KW - Expeditions

KW - Heart/physiopathology

KW - Humans

KW - Hypoxia/physiopathology

KW - Male

KW - Peru

U2 - 10.1113/EP088350

DO - 10.1113/EP088350

M3 - Article

C2 - 32237245

VL - 106

SP - 86

EP - 103

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 1

ER -