The effect of septal lesions on consumption of a sucrose solution containing 4.75% ethanol was assessed using two-bottle and one-bottle tests. Septal and control rats showed very similar levels of alcohol consumption in both tests. During two-bottle testing, both groups demonstrated a clear preference for sucrose solution. During the 15-min one-bottle test, alcohol intake was substantial (means = 2.93 and 2.95 ml/kg) and produced obvious symptoms of inebriation. It is concluded that self-administration of ethanol under these conditions is an appropriate method for brief studies of septal-ethanol interactions.